C ABL GENE Meaning and
Definition
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The c abl gene refers to a specific gene that encodes for a protein known as the Abelson tyrosine kinase (ABL). This gene is located on chromosome 9 in humans and is essential for proper cell growth, division, and differentiation. The ABL protein is involved in various cellular processes, particularly those related to signal transduction and regulation of the cell cycle.
Mutations or alterations in the c abl gene have been linked to the development of certain cancers, such as chronic myeloid leukemia (CML). In these cases, a specific mutation known as the Philadelphia chromosome translocation takes place, leading to the fusion of the c abl gene with another gene called BCR (breakpoint cluster region). This fusion gene is called BCR-ABL and results in the production of a constitutively active tyrosine kinase that promotes uncontrolled cell growth and division.
Targeting the activity of the BCR-ABL protein has proved to be a successful therapeutic approach in treating CML. Many targeted therapies, known as tyrosine kinase inhibitors (TKIs), have been developed to specifically inhibit the activity of the BCR-ABL protein, thereby preventing the proliferation of cancer cells. These TKIs have significantly improved survival rates and quality of life for patients with CML.
In summary, the c abl gene is a crucial component of cellular growth and regulation, and its abnormal activity, particularly due to the BCR-ABL fusion gene, is implicated in the development of certain cancers. Targeted therapies have been developed to specifically inhibit the abnormal activity of this gene in order to treat affected individuals.
Common Misspellings for C ABL GENE
- x abl gene
- v abl gene
- f abl gene
- d abl gene
- c zbl gene
- c sbl gene
- c wbl gene
- c qbl gene
- c avl gene
- c anl gene
- c ahl gene
- c agl gene
- c abk gene
- c abp gene
- c abo gene
- c abl fene
- c abl vene
- c abl bene
- c abl hene
- c abl yene
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