BOMBESIN RECEPTORS Meaning and
Definition
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Bombesin receptors are a class of G-protein coupled receptors that play a significant role in various physiological processes in the body. These receptors are activated by a peptide called bombesin, which is a neuropeptide found in the brain, gastrointestinal tract, and other tissues.
The bombesin receptors are classified into three subtypes: the gastrin-releasing peptide receptor (GRPR), the neuromedin B receptor (NMBR), and the bombesin receptor subtype 3 (BRS-3). These receptors are widely distributed throughout the body, including the brain, lungs, intestines, and reproductive organs.
The primary function of bombesin receptors is to regulate the release of several important hormones, including gastrin, cholecystokinin, and somatostatin. They are also involved in the regulation of gastrointestinal motility, gastric acid secretion, and smooth muscle contraction in the gut.
Furthermore, bombesin receptors are implicated in the pathophysiology of various diseases, including cancer. Their overexpression has been observed in several types of cancers, such as lung, prostate, and breast cancer. Targeting bombesin receptors with specific agonists or antagonists has shown potential therapeutic applications in the field of oncology.
In summary, bombesin receptors are a class of G-protein coupled receptors that regulate several physiological processes in the body. Their activation by bombesin peptide triggers various downstream signaling pathways involved in hormone release, gastrointestinal motility, and smooth muscle contraction. The dysregulation of bombesin receptors is associated with the development and progression of certain diseases, particularly cancer.
Common Misspellings for BOMBESIN RECEPTORS
- vombesin receptors
- nombesin receptors
- hombesin receptors
- gombesin receptors
- bimbesin receptors
- bkmbesin receptors
- blmbesin receptors
- bpmbesin receptors
- b0mbesin receptors
- b9mbesin receptors
- bonbesin receptors
- bokbesin receptors
- bojbesin receptors
- bomvesin receptors
- bomnesin receptors
- bomhesin receptors
- bomgesin receptors
- bombwsin receptors
- bombssin receptors
- bombdsin receptors
Etymology of BOMBESIN RECEPTORS
The word "Bombesin Receptors" is composed of two main components: "Bombesin" and "Receptors".
1. Bombesin:
The term "bombesin" is derived from the French word "bombesi", meaning "to bombard". The term was coined by Victoria Mutt, a French physiologist, in 1970. Bombesin is a peptide hormone initially isolated from amphibian skin, specifically the European fire-bellied toad (Bombina bombina), which is known for its defensive behaviors. Bombesin is also found in the human central nervous system and gastrointestinal tract, where it acts as a neuromodulator and regulates numerous physiological functions.
2. Receptors:
The term "receptors" comes from the Latin word "receptus", which means "to receive".
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