BOMBESIN RECEPTOR Meaning and
Definition
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Bombesin receptors are a class of cell surface receptors that are part of the G-protein-coupled receptor family. These receptors are primarily found in the central nervous system, gastrointestinal tract, lungs, and other tissues. They are involved in mediating various cellular processes and signaling pathways.
Bombesin receptors are named after the peptide ligand bombesin, which was initially isolated from the skin of frogs. The receptors are activated by bombesin and related peptides, leading to the initiation of downstream signaling cascades. These receptors play a crucial role in regulating a wide range of physiological functions such as neurotransmission, cell growth, hormone secretion, and smooth muscle contraction.
There are three main types of bombesin receptors, known as bombesin receptor subtype 1, 2, and 3 (BRS-1, BRS-2, and BRS-3). Each subtype has distinct tissue distribution, biological functions, and affinity for different peptides. BRS-1, for example, is primarily found in the central nervous system and is involved in regulating pain perception and feeding behavior. BRS-2 and BRS-3 are more widely distributed and have been implicated in various processes such as cell proliferation, tumor growth, and regulation of gastrointestinal motility.
Due to their involvement in multiple physiological and pathological processes, bombesin receptors have attracted interest as potential therapeutic targets for various diseases, including neurological disorders and certain types of cancers. Targeting these receptors with specific agonists or antagonists may offer potential therapeutic avenues for the development of novel drugs.
Common Misspellings for BOMBESIN RECEPTOR
- vombesin receptor
- nombesin receptor
- hombesin receptor
- gombesin receptor
- bimbesin receptor
- bkmbesin receptor
- blmbesin receptor
- bpmbesin receptor
- b0mbesin receptor
- b9mbesin receptor
- bonbesin receptor
- bokbesin receptor
- bojbesin receptor
- bomvesin receptor
- bomnesin receptor
- bomhesin receptor
- bomgesin receptor
- bombwsin receptor
- bombssin receptor
- bombdsin receptor
Etymology of BOMBESIN RECEPTOR
The word "bombesin receptor" is a scientific term derived from two different sources: "bombesin" and "receptor".
1. Bombesin: Bombesin is a peptide hormone that was first isolated and identified in 1971 from the skin of a frog, Bombina bombina. It was later discovered that bombesin is also present in mammals, including humans. The name "bombesin" is derived from the Latin word "bombus", which means "buzzing" or "humming". This name was chosen because it was found to stimulate the smooth muscles of the gastrointestinal tract, leading to contractions that resemble buzzing or humming sounds.
2. Receptor: In biology, a receptor refers to a specialized protein molecule that is located on the surface of cells or inside them.
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