ANTISENSE OLIGODNA Meaning and
Definition
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Antisense OligoDNA, also known as simply antisense oligonucleotide or ASO, is a specific type of synthetic DNA molecule that serves as a molecular tool in genetic research and therapy. It is designed to have a complementary sequence to the targeted RNA molecule, allowing it to bind and regulate its expression levels.
The "antisense" in its name refers to the fact that it is specifically designed to be the reverse complement of the target RNA sequence. This enables it to bind to the target RNA through base pairing, forming a stable double-stranded structure. This binding inhibits the normal function of the RNA molecule, preventing it from being translated into a protein or affecting its stability by promoting enzymatic degradation.
Antisense OligoDNAs are commonly used to study gene function, as they can provide valuable insights into the effects of altering specific gene expression levels. They can also be used as therapeutic agents in treating various genetic and viral diseases, where abnormal gene expression needs to be corrected. By specifically targeting disease-causing RNA molecules, antisense oligonucleotides can suppress the production of harmful proteins or prevent the expression of pathogenic genes.
The development of antisense oligonucleotide technology has revolutionized the field of molecular biology and medicine by providing a powerful strategy for gene regulation and therapy. However, delivery remains a challenge as these molecules are prone to degradation and are not efficiently taken up by cells. Ongoing research aims to optimize their design and delivery methods, paving the way for the development of more effective and targeted therapies.
Common Misspellings for ANTISENSE OLIGODNA
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Etymology of ANTISENSE OLIGODNA
The word "Antisense OligoDNA" can be broken down as follows:
1. Antisense:
- "Antisense" is derived from the combination of two words, "anti-" and "sense".
- "Anti-" is a prefix meaning "against" or "opposite to".
- "Sense" refers to the sequence or orientation of DNA that carries the genetic information in a particular direction.
- Therefore, "antisense" refers to a sequence of DNA that has been modified or designed to be complementary to a specific target sequence of DNA, which is known as the "sense" sequence. It acts as a mirror image or opposite to the sense sequence.
2. OligoDNA:
- "Oligo" comes from the Greek word "oligos", meaning "few" or "a small number of".
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