How Do You Spell AMIDE LINKAGE?

Pronunciation: [ɐmˈa͡ɪd lˈɪŋkɪd͡ʒ] (IPA)

The word "amide linkage" is spelled /ˈæmaɪd ˈlɪŋkɪdʒ/, with stress on the first syllable of each word. "Amide" is pronounced with three syllables, starting with the "a" as in "cat," followed by "mide" to rhyme with "tide." "Linkage" is pronounced with two syllables, starting with "link" to rhyme with "ink," followed by "-age" to rhyme with "sage." An amide linkage refers to the covalent bond between the nitrogen atom of an amide group and the carbon atom of another molecule.

AMIDE LINKAGE Meaning and Definition

1. An amide linkage, also referred to as a peptide linkage, is a chemical bond formed by the condensation reaction between a carboxylic acid group (-COOH) and an amino group (-NH2). It is an essential component found in the structure of proteins, which are vital biomolecules responsible for various biological functions.

   The amide linkage is formed through a reaction called an amidation, in which the carboxylic acid group loses a water molecule (-H2O). This reaction occurs when the carbonyl carbon from the carboxylic acid group reacts with the nitrogen from the amino group. The resulting structure is a peptide bond (-CO-NH-), which links the amino acid residues together, forming a polypeptide chain.

   The amide linkage is incredibly strong and stable, making peptides and proteins resistant to hydrolysis. This strength is due to the delocalization of electrons within the amide group, resulting in a partial double bond character within the bond. It possesses an overall planar structure due to the presence of rigid bonds, making it more resistant to rotation and conformational changes.

   The amide linkage plays a crucial role in protein structure and function, as it determines the primary structure of a protein chain. The specific sequence of amino acid residues connected by amide linkages dictates the protein's unique properties, including its shape, function, and interactions with other molecules. Understanding the amide linkage is vital in studying protein folding, enzymatic reactions, and drug design, as it provides insights into the chemical nature and stability of proteins.

Common Misspellings for AMIDE LINKAGE

• zmide linkage
• smide linkage
• wmide linkage
• qmide linkage
• anide linkage
• akide linkage
• ajide linkage
• amude linkage
• amjde linkage
• amkde linkage
• amode linkage
• am9de linkage
• am8de linkage
• amise linkage
• amixe linkage
• amice linkage
• amife linkage
• amire linkage
• amiee linkage
• amidw linkage

Etymology of AMIDE LINKAGE

The word "amide" derives from the Latin word "amidum", which means starch. In organic chemistry, "amides" refer to a class of compounds that are derived from ammonia, where one or more hydrogen atoms are replaced by acyl groups. These acyl groups are derived from carboxylic acids.

The term "linkage" simply refers to the connection or bond between two atoms or groups within a molecule. In the case of "amide linkage", it specifically refers to the bond formed between the nitrogen atom of an amide and the carbon atom of a carbonyl group (-C=O).

Therefore, the term "amide linkage" simply combines the terms "amide" and "linkage" to describe the specific bond or connection present in amides.

Plural form of AMIDE LINKAGE is AMIDE LINKAGES