ALDOLASE B Meaning and
Definition
-
Aldolase B is an enzyme that is primarily found in the liver, kidney, and small intestine of humans. It is responsible for catalyzing the reversible cleavage of fructose 1-phosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde. This enzymatic reaction is a vital step in the metabolism of fructose.
The function of Aldolase B is specifically important in a metabolic pathway called fructose metabolism. It helps in the breakdown of fructose and the subsequent conversion of its energy into usable forms by the body. Deficiency or malfunctioning of Aldolase B can lead to a rare inherited metabolic disorder called hereditary fructose intolerance (HFI).
In individuals with HFI, the absence or reduced activity of Aldolase B results in an accumulation of fructose 1-phosphate in liver cells. This results in severe symptoms such as nausea, vomiting, abdominal pain, and hypoglycemia when fructose or sucrose is consumed. Long-term exposure to fructose can also cause liver and kidney damage in individuals with HFI.
Medical intervention for HFI generally involves a strict dietary fructose restriction, as well as the avoidance of sucrose and its derivatives. Genetic testing can identify mutations in the ALDOB gene that codes for Aldolase B, enabling early detection and management of HFI.
Overall, Aldolase B is an essential enzyme that plays a crucial role in fructose metabolism, and its deficiency can lead to severe metabolic disturbances in individuals with hereditary fructose intolerance.
Common Misspellings for ALDOLASE B
- zldolase b
- sldolase b
- wldolase b
- qldolase b
- akdolase b
- apdolase b
- aodolase b
- alsolase b
- alxolase b
- alcolase b
- alfolase b
- alrolase b
- aleolase b
- aldilase b
- aldklase b
- aldllase b
- aldplase b
- ald0lase b
- ald9lase b
- aldokase b
Etymology of ALDOLASE B
The word "Aldolase B" has a specific etymology related to its scientific nomenclature.
1. Aldolase: The term "aldolase" comes from the combination of two words - "aldol" and "-ase". "Aldol" refers to a chemical reaction known as aldol condensation, which involves the formation of an aldol molecule by combining an aldehyde and a ketone. The suffix "-ase" is commonly used in biochemistry to denote an enzyme. Therefore, "aldolase" refers to an enzyme involved in aldol condensation reactions.
2. B: The letter "B" in "Aldolase B" is used to differentiate it from other forms or isoenzymes of aldolase. In biochemistry, different forms of enzymes may exist, each differentiated by a letter or other designations.
Infographic
Add the infographic to your website:
