VARIABLE REGION Meaning and
Definition
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Variable Region refers to a specific region within a molecule, usually a protein, that exhibits a high degree of variability in its amino acid sequence. In proteins, variable regions are commonly found in the immunoglobulins, which are also known as antibodies. These regions are responsible for recognizing and binding to specific antigens, such as foreign molecules or pathogens, thereby initiating an immune response.
The variable region of an immunoglobulin consists of two parts: the variable heavy (VH) region and the variable light (VL) region. These regions contain a diverse repertoire of genes that can be rearranged during the development of B-cells, leading to the generation of an enormous number of unique antibody molecules. This diversity allows the immune system to recognize and respond to a wide range of antigens.
The amino acid sequence within the variable region plays a critical role in determining the specificity and affinity of antibody binding to its target antigen. Through the process of somatic hypermutation, B-cells can further modify the amino acid sequence of the variable region, leading to the production of antibodies with enhanced binding properties.
In summary, the variable region is a crucial component of proteins, particularly immunoglobulins, that provide specificity and diversity in binding to antigens, enabling the immune system to generate a tailored response against various threats.
Common Misspellings for VARIABLE REGION
- cariable region
- bariable region
- gariable region
- fariable region
- vzriable region
- vsriable region
- vwriable region
- vqriable region
- vaeiable region
- vadiable region
- vafiable region
- vatiable region
- va5iable region
- va4iable region
- varuable region
- varjable region
- varkable region
- varoable region
- var9able region
- var8able region
Etymology of VARIABLE REGION
The term "Variable Region" originated from the field of molecular biology and immunology. Its etymology can be broken down as follows:
1. Variable: This word comes from the Latin word "variabilis", derived from the verb "variare", meaning "to change" or "to vary". In scientific usage, it refers to an element or factor that can exhibit variation or change.
2. Region: This term has its roots in the Latin word "regio", meaning "boundary" or "area". In this context, it denotes a specific area or segment within a larger structure or organism.
When these two terms are combined, "Variable Region" refers to a specific portion or segment of a larger molecule or protein that is known to exhibit variation or diversity among different individuals or species.
