How Do You Spell VAL TRNA LIGASE?

Pronunciation: [vˈal tˈiː ˌɑːɹˌɛnˈe͡ɪ lˈɪɡe͡ɪs] (IPA)

The spelling of "Val tRNA Ligase" is based on the International Phonetic Alphabet (IPA) phonetic transcription system. In IPA, "Val" is pronounced as "væl," with a short "a" sound and an "l" at the end. "tRNA" is pronounced as "tiː ɑːr ɛn eɪ," with a long "i," a long "a," and an "n" at the end. "Ligase" is pronounced as "laɪɡeɪs," with a long "i," a soft "g," and an "s" at the end. All of these phonetic elements come together to create the spelling of "Val tRNA Ligase."

VAL TRNA LIGASE Meaning and Definition

1. Val tRNA Ligase, also known as Valyl-tRNA Synthetase or VARS, is an enzyme that plays a crucial role in protein synthesis. It is classified as a ligase enzyme and is responsible for catalyzing the attachment of valine amino acids to their corresponding transfer RNA (tRNA) molecules during the process of translation.

   Val tRNA Ligase specifically recognizes and binds to transfer RNA molecules carrying the amino acid valine. The enzyme carries out a two-step reaction by first activating the valine amino acid through the hydrolysis of ATP (adenosine triphosphate). This generates an activated valine molecule, which is then transferred to the 3'-end of the tRNA molecule.

   This enzymatic process, known as aminoacylation or charging of tRNA, is an essential step in translation. The charged tRNA molecules then deliver the valine amino acids to the ribosome, where they participate in peptide bond formation during protein synthesis. By ensuring the accurate attachment of valine to tRNA, Val tRNA Ligase contributes to the fidelity and efficiency of protein synthesis.

   Mutations or dysfunctions in the VARS gene, which encodes the Val tRNA Ligase enzyme, can lead to various disorders, including neurodevelopmental disorders and Charcot-Marie-Tooth disease. Furthermore, Val tRNA Ligase has been identified as a potential target for the development of antibiotics, as disrupting its activity can impair bacterial protein synthesis and inhibit microbial growth.

Common Misspellings for VAL TRNA LIGASE

• cal trna ligase
• bal trna ligase
• gal trna ligase
• fal trna ligase
• vzl trna ligase
• vsl trna ligase
• vwl trna ligase
• vql trna ligase
• vak trna ligase
• vap trna ligase
• vao trna ligase
• val rrna ligase
• val frna ligase
• val grna ligase
• val yrna ligase
• val 6rna ligase
• val 5rna ligase
• val tena ligase
• val tdna ligase
• val tfna ligase