TYROSINE AMINOTRANSFERASE Meaning and
Definition
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Tyrosine aminotransferase is an enzyme that plays a crucial role in the metabolism of the amino acid tyrosine. It is specifically involved in the conversion of tyrosine to 4-hydroxyphenylpyruvate. This enzyme is part of the larger family of aminotransferases, which catalyze the transfer of an amino group from an amino acid to a specific keto acid.
Tyrosine aminotransferase is primarily found in the liver and kidney tissues of organisms, where it participates in the breakdown of tyrosine. It is an important enzyme in the tyrosine catabolic pathway, which is responsible for the production of metabolic intermediates involved in energy production and the synthesis of various molecules.
The substrate specificity of tyrosine aminotransferase allows it to selectively act on tyrosine and enables the transfer of its amino group to an α-keto acid. The resulting product of this reaction, 4-hydroxyphenylpyruvate, can further undergo enzymatic conversions leading to the formation of homogentisic acid and eventually to the synthesis of important molecules such as catecholamines and melanin.
Mutations or deficiencies in tyrosine aminotransferase can lead to metabolic disorders, such as type II tyrosinemia, characterized by an accumulation of toxic intermediates in the body. As a result, individuals with this condition may experience symptoms such as liver dysfunction, neurological abnormalities, and development delays.
In summary, tyrosine aminotransferase is an enzyme that plays a vital role in the catabolism of tyrosine, facilitating the production of important metabolic intermediates essential for various biological processes.
Common Misspellings for TYROSINE AMINOTRANSFERASE
- ryrosine aminotransferase
- fyrosine aminotransferase
- gyrosine aminotransferase
- yyrosine aminotransferase
- 6yrosine aminotransferase
- 5yrosine aminotransferase
- ttrosine aminotransferase
- tgrosine aminotransferase
- throsine aminotransferase
- turosine aminotransferase
- t7rosine aminotransferase
- t6rosine aminotransferase
- tyeosine aminotransferase
- tydosine aminotransferase
- tyfosine aminotransferase
- tytosine aminotransferase
- ty5osine aminotransferase
- ty4osine aminotransferase
- tyrisine aminotransferase
- tyrksine aminotransferase
Etymology of TYROSINE AMINOTRANSFERASE
The word "tyrosine aminotransferase" can be broken down into two parts: "tyrosine" and "aminotransferase".
1. Tyrosine: The term "tyrosine" originates from the Greek word "tyros", meaning cheese. It was first isolated from cheese in the 19th century. The word "tyrosine" specifically refers to an amino acid that is essential for the synthesis of various proteins in the body.
2. Aminotransferase: The word "aminotransferase" consists of two components - "amino" and "transferase".
- "Amino" originates from the Latin word "aminum", referring to ammonia. In the context of this word, it indicates the presence of an amino group (-NH2) in the molecule.
