How Do You Spell TUMOR SUPPRESSING GENE?

Pronunciation: [tjˈuːmə səpɹˈɛsɪŋ d͡ʒˈiːn] (IPA)

The phrase "tumor suppressing gene" refers to a gene that inhibits the development of tumors. The spelling of this phrase follows the English language's general orthographic conventions, which use the letters "o" and "u" to represent the vowel sounds /oʊ/ and /ʌ/ respectively. The IPA phonetic transcription of "tumor suppressing gene" is /ˈtuː.mɚ səˈprɛs.ɪŋ dʒin/, with stress on the first syllable of "tumor" and the second syllable of "suppressing".

TUMOR SUPPRESSING GENE Meaning and Definition

1. A tumor suppressing gene refers to a class of genes that play a crucial role in preventing the formation and development of tumors or cancers within the body. These genes act as regulatory molecules, controlling cell growth, division, and apoptosis (programmed cell death). Tumor suppressing genes are responsible for suppressing the growth of abnormal or mutated cells, ensuring their elimination and maintaining the correct balance of cell proliferation.

   When tumor suppressing genes undergo mutations or get silenced, they lose their ability to suppress tumor formation. This can lead to uncontrolled cell growth and the development of cancer. In normal cells, tumor suppressing genes act as a "brake" mechanism that halts or slows down cell division when necessary, preventing the formation of excessive, abnormal cell masses. They also repair DNA damage and encourage damaged cells to self-destruct, which prevents the accumulation of potentially harmful mutations.

   Numerous tumor suppressing genes have been identified, including well-known examples, such as p53 and BRCA1. Mutations in these genes are associated with an increased risk of various types of cancers. Understanding the functions and mechanisms of tumor suppressing genes is crucial in the field of cancer research, as it helps scientists develop targeted therapies and preventive strategies to counteract the loss or dysfunction of these vital cellular regulators.

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