TRANSGLUTAMINASES Meaning and
Definition
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Transglutaminases (TGs) refer to a family of enzymes that facilitate the formation of covalent bonds between proteins or peptides. These enzymes have an important role in various biological processes, including tissue development, blood clot formation, and the repair of wounds. The name "transglutaminases" is derived from their ability to catalyze the transfer of the gamma carboxamide group of protein-bound glutamine residues to the epsilon-amino group of lysine residues in other proteins or peptides.
TGs play a crucial role in the process of protein crosslinking, also known as transamidation or transglutamination, which helps to stabilize protein structures. By forming these stable intermolecular bonds, TGs enhance the mechanical strength and structural integrity of proteins. This crosslinking process is particularly crucial for the formation of the protein network in tissues like skin and hair.
In addition to their role in protein crosslinking, transglutaminases are involved in various other physiological functions. For instance, they play a role in blood clotting by promoting the linkage of fibrin polymers, which is essential for maintaining hemostasis. Transglutaminases have also been associated with the regulation of immune responses, cell adhesion, and programmed cell death.
Overall, transglutaminases are a group of enzymes that facilitate the formation of covalent bonds between proteins or peptides, playing a vital role in various biological processes, including tissue development, blood clotting, and wound repair.
Common Misspellings for TRANSGLUTAMINASES
- rransglutaminases
- fransglutaminases
- gransglutaminases
- yransglutaminases
- 6ransglutaminases
- 5ransglutaminases
- teansglutaminases
- tdansglutaminases
- tfansglutaminases
- ttansglutaminases
- t5ansglutaminases
- t4ansglutaminases
- trznsglutaminases
- trsnsglutaminases
- trwnsglutaminases
- trqnsglutaminases
- trabsglutaminases
- tramsglutaminases
- trajsglutaminases
- trahsglutaminases
Etymology of TRANSGLUTAMINASES
The word "transglutaminases" is derived from two main components: "trans" and "glutaminases".
"Trans-" is a prefix that means "across" or "on the other side of" in Latin. It is often used in English to indicate movement, change, or transfer.
"Glutaminases" refers to a group of enzymes called "glutaminase". The term "glutaminase" is formed from "glutamine" and the suffix "-ase".
"Glutamine" is an amino acid that is an essential component of proteins and is widely distributed in living organisms.
The suffix "-ase" is commonly used in biology to denote enzymes. Enzymes are proteins that catalyze chemical reactions in living organisms.
Therefore, "transglutaminases" refers to a group of enzymes that transfer or catalyze reactions involving glutamine or its derivatives.
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