How Do You Spell THYMIDYLATE SYNTHETASE?

Pronunciation: [θˈa͡ɪmɪdˌɪle͡ɪt sˈɪnθɪtˌe͡ɪs] (IPA)

Thymidylate Synthetase is a mouthful of a word, but its spelling is actually pretty straightforward if you break it down phonetically. The first syllable "thy" rhymes with "eye," the "mi" is pronounced like "me," and "dylate" sounds like "dilate." "Synthetase" starts with a "synth" sound like "sin," followed by "et" like "ate," and ends with "ase" pronounced like "ace." So, it's pronounced "thy-mi-dil-ate sin-thet-ace." This enzyme is involved in DNA synthesis, so it's an important word to know for those studying biology and genetics.

THYMIDYLATE SYNTHETASE Meaning and Definition

1. Thymidylate synthetase is an enzyme that plays a crucial role in the production of thymidine, which is an essential component of DNA. Also known as thymidylate synthase, this enzyme is responsible for catalyzing the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP is a precursor for thymidine triphosphate (dTTP), one of the building blocks of DNA.

   Thymidylate synthetase is an integral part of the process known as DNA synthesis, and it ensures the accurate replication of DNA during cell division. The enzyme achieves this by catalyzing the addition of a methyl group from 5,10-methylenetetrahydrofolate (CH2THF) to dUMP, resulting in the formation of dTMP. This reaction is essential for maintaining the balance of nucleotides and providing an adequate supply of thymidine for DNA replication.

   The activity of thymidylate synthetase is highly regulated, as its inhibition can disrupt DNA synthesis and have detrimental effects on cell growth and proliferation. Many chemotherapeutic agents used in cancer treatment, such as fluoropyrimidines and antifolates, target thymidylate synthetase to inhibit its activity and prevent DNA replication in rapidly dividing cancer cells.

   Understanding the biochemical properties and structure of thymidylate synthetase has been of significant interest in the pharmaceutical industry, as it provides valuable insights for developing novel therapeutic agents that may selectively target this enzyme for various diseases, including cancer and microbial infections.

Common Misspellings for THYMIDYLATE SYNTHETASE

• rhymidylate synthetase
• fhymidylate synthetase
• ghymidylate synthetase
• yhymidylate synthetase
• 6hymidylate synthetase
• 5hymidylate synthetase
• tgymidylate synthetase
• tbymidylate synthetase
• tnymidylate synthetase
• tjymidylate synthetase
• tuymidylate synthetase
• tyymidylate synthetase
• thtmidylate synthetase
• thgmidylate synthetase
• thhmidylate synthetase
• thumidylate synthetase
• th7midylate synthetase
• th6midylate synthetase
• thynidylate synthetase
• thykidylate synthetase

Etymology of THYMIDYLATE SYNTHETASE

The word "thymidylate" is derived from "thymidine", which is a nucleotide composed of a deoxyribose sugar linked to thymine (one of the four DNA bases). The term "synthetase" refers to an enzyme that catalyzes the synthesis of a specific molecule.

Therefore, "thymidylate synthetase" is an enzyme responsible for synthesizing thymidylate, also known as deoxythymidine monophosphate (dTMP). It plays a crucial role in DNA replication and synthesis by converting deoxyuridine monophosphate (dUMP) into dTMP.