TCRDELTA, also known as T-cell receptor delta, refers to a specific type of T-cell receptor that is found on the surface of T-cells, a type of white blood cell involved in the immune response. The T-cell receptor delta plays a crucial role in the recognition and activation of T-cells in response to foreign antigens.
The TCRDELTA is a protein complex composed of two chains, namely delta and gamma chains, which form a heterodimer. This heterodimer structure distinguishes it from other T-cell receptors, such as TCRALPHA and TCRBETA, which are composed of two identical chains. The TCRDELTA is primarily associated with a subset of T-cells known as TCR-gammadelta T-cells.
TCRDELTA is responsible for recognizing and binding to antigens in a major histocompatibility complex (MHC)-independent manner. This means that unlike other T-cell receptors, TCRDELTA is not restricted to recognizing antigens presented by MHC molecules. It allows TCR-gammadelta T-cells to detect a broad range of antigens, including those derived from microbial infections and stress-induced molecules.
The TCRDELTA is involved in various immune responses, including the activation and proliferation of TCR-gammadelta T-cells. These specialized T-cells are particularly abundant at mucosal surfaces and are known to play important roles in immune surveillance and response against bacterial, viral, and fungal infections. They also participate in the regulation of inflammation and immune tolerance, as well as in the recognition and elimination of cancerous cells.
In summary, TCRDELTA refers to a specific type of T-cell receptor, present on TCR-gammadelta T-cells, responsible for recognizing a wide range
