TCR GENES Meaning and
Definition
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T-cell receptor (TcR) genes refer to a group of genes responsible for encoding the T-cell receptor proteins found on the surface of T lymphocytes, a type of white blood cell involved in the immune response. T-cell receptors are crucial for the recognition and elimination of foreign pathogens, such as viruses or bacteria, as well as abnormal cells in the body.
The TcR genes are located on specific regions of the chromosomes, primarily on chromosome 7 in humans. These genes undergo a complex process of somatic recombination, whereby diverse combinations of gene segments are randomly rearranged to assemble a functional T-cell receptor gene. This recombination process allows for the generation of an extensive repertoire of T-cell receptors, enabling the immune system to recognize a wide range of antigens.
TcR genes can be divided into two main types: alpha (α) and beta (β) chains. Each of these chains consists of variable (V), diversity (D), and joining (J) gene segments. The α and β chains combine to form a functional T-cell receptor complex, which is responsible for detecting specific antigens and initiating an immune response.
Mutations or abnormalities in TcR genes can lead to various immunological disorders, such as immune deficiencies or autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. Research in TcR genes has provided valuable insights into the development, function, and diversity of T cells, contributing to our understanding of immune responses and the development of therapeutic interventions targeting T-cell mediated diseases.
Common Misspellings for TCR GENES
- rcr genes
- fcr genes
- gcr genes
- ycr genes
- 6cr genes
- 5cr genes
- txr genes
- tvr genes
- tfr genes
- tdr genes
- tce genes
- tcd genes
- tcf genes
- tc5 genes
- tc4 genes
- tcr fenes
- tcr venes
- tcr benes
- tcr henes
- tcr yenes
Etymology of TCR GENES
The term "TcR Genes" is an abbreviation that stands for "T-cell Receptor Genes".
The etymology of "T-cell" derives from the fact that these cells, also known as T lymphocytes, are primarily developed in the thymus gland. The name "T-cell" was coined in the 1960s, with the "T" referring to thymus.
The "Receptor" part of the term refers to the function of the T-cell receptor. T-cell receptors are proteins located on the surface of T-cells that recognize and bind to specific antigens, initiating an immune response. The word "Receptor" comes from the Latin word "recipere", which means "to receive".
"Genes" is a term derived from the Greek word "génos", meaning "race" or "kind".
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