SPINDLE CELL Meaning and
Definition
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Spindle cell refers to a type of cell that displays a characteristic elongated, spindle-shaped morphology. It is a term commonly used in the field of pathology and histology to describe cells that have distinct elongated nuclei, and a narrow, elongated cytoplasm. These cells typically have a uniform appearance along their length, resembling a spindle or elongated oval shape, with tapered and pointed ends.
Spindle cells can arise from various tissue types and can be found in a range of conditions. In pathology, the presence of spindle cells can indicate a variety of neoplastic or non-neoplastic processes. Some examples include certain types of sarcomas, such as gastrointestinal stromal tumors, leiomyosarcomas, and malignant melanomas. Inflammatory conditions such as infections and certain autoimmune diseases can also cause the proliferation of spindle cells.
The distinct spindle cell morphology can be visualized using microscopic examination of tissue samples, such as biopsies or surgical specimens. Specialized staining techniques, such as immunohistochemistry, may also be employed to aid in the identification and characterization of these cells.
Understanding the presence and nature of spindle cells is crucial in making accurate diagnoses and determining appropriate treatment plans. Further investigations, including molecular testing and clinical correlation, are often necessary to elucidate the underlying cause and guide clinical management.
Etymology of SPINDLE CELL
The word "spindle" in "spindle cell" originates from the Old English word "spindel" or "spinnan", meaning "a slender, tapering object". It is derived from the Proto-Germanic word "spindulaz", which refers to a spinning implement used for thread.
The term "spindle cell" specifically emerged in the late 19th century in the field of pathology to describe a particular type of cell with an elongated, tapered shape resembling a spindle or needle. It was coined based on the resemblance of the cells to the shape of a spindle used in textile production. These spindle cells are seen commonly in certain tumors, including sarcomas and carcinomas, and are characterized by their elongated shape and central nucleus.
