SELENOGLUTATHIONE PEROXIDASE Meaning and
Definition
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Selenoglutathione peroxidase is an enzyme found in living organisms that plays a crucial role in antioxidant defense. It belongs to the family of glutathione peroxidases (GPx), which are responsible for protecting cells against oxidative damage by reducing peroxides such as hydrogen peroxide and lipid hydroperoxides. What sets selenoglutathione peroxidase apart from other GPx enzymes is its unique dependence on selenium.
Selenium is an essential trace mineral that forms an integral component of selenoglutathione peroxidase's active site. This mineral is incorporated into the enzyme during its biosynthesis, resulting in the formation of a selenocysteine residue. This selenocysteine residue acts as a catalyst, facilitating the reduction of peroxides present in the cell.
Selenoglutathione peroxidase is mainly localized in the cytoplasm and mitochondria of cells, where it helps protect against reactive oxygen species (ROS) that can arise as byproducts of cellular metabolism or during times of stress. It achieves this by converting peroxides into water and by utilizing glutathione – a potent intracellular antioxidant that readily reacts with peroxides.
Through its antioxidant activity, selenoglutathione peroxidase helps maintain cellular redox balance and protects against oxidative stress-induced damage. Dysfunction or deficiency of this enzyme has been associated with various pathological conditions, including neurodegenerative diseases, cardiovascular disorders, and cancer.
In summary, selenoglutathione peroxidase is an enzyme that relies on selenium and glutathione to convert peroxides into harmless compounds. Its main role is to defend cells against oxidative damage, ensuring their proper functioning and survival.
Common Misspellings for SELENOGLUTATHIONE PEROXIDASE
- aelenoglutathione peroxidase
- zelenoglutathione peroxidase
- xelenoglutathione peroxidase
- delenoglutathione peroxidase
- eelenoglutathione peroxidase
- welenoglutathione peroxidase
- swlenoglutathione peroxidase
- sslenoglutathione peroxidase
- sdlenoglutathione peroxidase
- srlenoglutathione peroxidase
- s4lenoglutathione peroxidase
- s3lenoglutathione peroxidase
- sekenoglutathione peroxidase
- sepenoglutathione peroxidase
- seoenoglutathione peroxidase
- selwnoglutathione peroxidase
- selsnoglutathione peroxidase
- seldnoglutathione peroxidase
- selrnoglutathione peroxidase
- sel4noglutathione peroxidase
Etymology of SELENOGLUTATHIONE PEROXIDASE
The word "Selenoglutathione Peroxidase" can be broken down into its components to understand its etymology:
1. Seleno: This prefix comes from the element selenium (symbol Se), which is incorporated into the enzyme structure. Selenium is an essential trace element present in certain proteins that play important roles in various biological processes.
2. Glutathione: Glutathione is a tripeptide molecule involved in various biological reactions, particularly in antioxidant defense mechanisms. It consists of three amino acids: glutamate, cysteine, and glycine.
3. Peroxidase: This suffix refers to an enzyme that catalyzes the oxidation of a substrate using peroxide as a co-substrate. Peroxidases are involved in various processes, such as immune response, detoxification, and biosynthesis.
