RNA SPLICING Meaning and
Definition
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RNA splicing is a post-transcriptional modification process that takes place in eukaryotic cells, including those of plants, animals, and fungi. It involves the removal of introns, which are non-coding sequences, from the pre-messenger RNA (pre-mRNA) molecule, and the joining of the remaining coding sequences called exons to produce the mature mRNA transcript. The splicing process is fundamental for gene expression regulation and plays a crucial role in the formation of different protein isoforms from a single gene.
The splicing of RNA is carried out by a large protein-RNA complex called the spliceosome, which recognizes specific nucleotide sequences at the intron-exon boundaries, known as splice sites. This recognition ensures the precise removal of introns and the accurate joining of exons. In addition to these canonical splice sites, alternative splicing allows for the inclusion or exclusion of different exons or introns, resulting in the generation of multiple mRNA isoforms from a single gene. This process contributes significantly to protein diversity and gene regulation.
RNA splicing is a tightly regulated and highly dynamic process, influenced by various factors such as cell type, developmental stage, and environmental conditions. Defects or dysregulation in RNA splicing have been associated with a wide range of genetic diseases, including cancers, neurodegenerative disorders, and various developmental defects.
In summary, RNA splicing is a cellular process that removes non-coding sequences, or introns, from pre-mRNA molecules and joins the remaining coding sequences, or exons, to produce mature mRNA transcripts, thus enabling the production of multiple protein isoforms and regulating gene expression.
Common Misspellings for RNA SPLICING
- ena splicing
- dna splicing
- fna splicing
- tna splicing
- 5na splicing
- 4na splicing
- rba splicing
- rma splicing
- rja splicing
- rha splicing
- rnz splicing
- rns splicing
- rnw splicing
- rnq splicing
- rna aplicing
- rna zplicing
- rna xplicing
- rna dplicing
- rna eplicing
- rna wplicing
Etymology of RNA SPLICING
The word "RNA splicing" has a straightforward etymology.
The term "RNA" refers to "ribonucleic acid", which is a nucleic acid molecule involved in various biological functions, including carrying genetic information and synthesizing proteins.
The word "splicing" comes from the Old English word "splēotan", meaning "to split". Over time, the word "splicing" evolved to mean joining or connecting two different parts together.
Therefore, "RNA splicing" refers to the process of joining or connecting different segments, called exons and introns, within an RNA molecule to produce a final mRNA (messenger RNA) product for protein synthesis.
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