The spelling of the word "Rifathyroin" can seem difficult at first, but it is actually quite phonetic. The pronunciation is /rɪfəˈθʌɪrɔɪn/. The "r" and "i" at the beginning are pronounced separately, followed by a stressed "a" sound in the third syllable. The "th" in the middle is pronounced as a voiceless dental fricative, like the "th" in "think". The final syllable has a long "oi" sound, pronounced like "oy". So, while the spelling may be daunting, the pronunciation is straightforward once you understand the IPA phonetic transcription.