RIBONUCLEASE H Meaning and
Definition
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Ribonuclease H (RNase H) refers to a family of enzymes that are responsible for the degradation and removal of RNA from a DNA/RNA hybrid molecule. These enzymes cleave the phosphodiester bonds in the RNA strand of the hybrid, resulting in the release of the RNA fragment and leaving a DNA molecule intact.
Ribonuclease H enzymes are found in various organisms, including viruses, bacteria, and eukaryotes, and they play vital roles in various biological processes. The enzymes are categorized into two major classes: RNase H1, primarily found in eukaryotes, and RNase H2, present in both prokaryotes and eukaryotes. They differ in their substrate specificities and cofactor requirements.
The main function of ribonuclease H is to remove RNA primers during DNA replication. In this process, RNA primers are synthesized by primase and are later replaced with DNA. Ribonuclease H recognizes the RNA-DNA hybrid and specifically cleaves the RNA strand, allowing DNA polymerase to fill the gap with DNA. Consequently, ribonuclease H also plays a role in DNA repair mechanisms.
In addition to its natural functions, ribonuclease H has been widely used in molecular biology research. It is utilized in various techniques, such as reverse transcription polymerase chain reaction (RT-PCR), quantitative PCR (qPCR), and DNA sequencing, where RNA removal is crucial to obtain accurate DNA-related results. Furthermore, the study of ribonuclease H has contributed to a better understanding of DNA replication, transcription, and repair processes.
Common Misspellings for RIBONUCLEASE H
- eibonuclease h
- dibonuclease h
- fibonuclease h
- tibonuclease h
- 5ibonuclease h
- 4ibonuclease h
- rubonuclease h
- rjbonuclease h
- rkbonuclease h
- robonuclease h
- r9bonuclease h
- r8bonuclease h
- rivonuclease h
- rinonuclease h
- rihonuclease h
- rigonuclease h
- ribinuclease h
- ribknuclease h
- riblnuclease h
- ribpnuclease h
Etymology of RIBONUCLEASE H
The word "Ribonuclease H" is a compound term comprising two distinct components.
1. Ribonuclease: The term "ribonuclease" is derived from three components - "ribo-", "-nucle-", and "-ase".
- "ribo-" is derived from ribose, which is a sugar molecule found in RNA (ribonucleic acid).
- "-nucle-" is derived from "nucleic acid", which refers to the macromolecules that include both RNA and DNA (deoxyribonucleic acid).
- "-ase" is a suffix commonly used to indicate an enzyme.
2. H: The "H" in "Ribonuclease H" specifically refers to the type of ribonuclease it is. Ribonuclease H is an enzyme that specifically cleaves the RNA strand of RNA-DNA hybrids.
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