PYRIDOXINEPHOSPHATE OXIDASE Meaning and
Definition
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Pyridoxinephosphate oxidase is an enzyme that plays a crucial role in the metabolism of vitamin B6, specifically in the conversion of pyridoxine phosphate (PNP) to pyridoxal phosphate (PLP). It is an essential enzyme for the proper functioning of various biological processes, as PLP serves as a cofactor for over 100 different enzymes involved in amino acid metabolism, neurotransmitter synthesis, and other vital cellular reactions.
Pyridoxinephosphate oxidase functions by catalyzing the oxidation of PNP, a form of vitamin B6, using molecular oxygen. This process results in the formation of PLP, the active form of vitamin B6 that is readily available for use by the body.
The enzyme's catalytic activity requires the presence of certain metal ions, especially magnesium, and other cofactors. Pyridoxinephosphate oxidase is found in various tissues, including the liver, kidney, brain, and red blood cells, indicating its importance in different physiological functions.
Deficiencies or abnormalities in pyridoxinephosphate oxidase activity can lead to vitamin B6 deficiency, resulting in various symptoms, such as neurological disorders, impaired cognitive function, dermatological issues, and anemia. Identifying and understanding the role of this enzyme is essential for developing treatments for conditions associated with vitamin B6 deficiencies or dysfunctions.
Common Misspellings for PYRIDOXINEPHOSPHATE OXIDASE
- oyridoxinephosphate oxidase
- lyridoxinephosphate oxidase
- -yridoxinephosphate oxidase
- 0yridoxinephosphate oxidase
- ptridoxinephosphate oxidase
- pgridoxinephosphate oxidase
- phridoxinephosphate oxidase
- puridoxinephosphate oxidase
- p7ridoxinephosphate oxidase
- p6ridoxinephosphate oxidase
- pyeidoxinephosphate oxidase
- pydidoxinephosphate oxidase
- pyfidoxinephosphate oxidase
- pytidoxinephosphate oxidase
- py5idoxinephosphate oxidase
- py4idoxinephosphate oxidase
- pyrudoxinephosphate oxidase
- pyrjdoxinephosphate oxidase
- pyrkdoxinephosphate oxidase
- pyrodoxinephosphate oxidase
Etymology of PYRIDOXINEPHOSPHATE OXIDASE
The word "pyridoxinephosphate oxidase" is composed of several elements derived from different sources:
1. Pyridoxine: This term comes from the chemical compound called pyridoxine, an organic compound that is one of the forms of vitamin B6.
2. Phosphate: This term comes from the chemical term "phosphate", which refers to a compound containing the phosphate ion (PO43-). It is derived from the Greek word "phosphoros", meaning "light-bearing" or "light-bringer".
3. Oxidase: This term comes from the enzyme class called oxidases, which are responsible for catalyzing oxidation-reduction reactions in which oxygen is often involved. The term "oxidase" is derived from the Greek word "oxys", meaning "sharp" or "acid", and the suffix "-ase", indicating an enzyme.
