How Do You Spell PYRAZINAMIDE?

Pronunciation: [pˈɪɹe͡ɪzˌɪnɐmˌa͡ɪd] (IPA)

Pyrazinamide is a medication commonly used to treat tuberculosis. Its spelling can be a bit tricky to decipher. It is pronounced as pɪˌraːzɪˈnæmʌɪd, with the stress on the second syllable. The first part of the word, "pyrazin," comes from the pyrazine ring structure in the molecule, while the "amide" suffix refers to the molecule's functional group. The word's tricky spelling is due to its complex structure, which includes multiple vowels, consonants, and syllables. Fortunately, learning how to spell Pyrazinamide can be made easier with practice and phonetic transcription.

PYRAZINAMIDE Meaning and Definition

1. Pyrazinamide is a synthetic compound that belongs to the class of antimycobacterial drugs. It is primarily used in the treatment of tuberculosis (TB) and is often prescribed as part of a multidrug regimen. Pyrazinamide exhibits bactericidal activity against certain strains of Mycobacterium tuberculosis, the bacteria responsible for causing TB.

   The mode of action of pyrazinamide is not fully understood, but it is believed to disrupt the biosynthesis of certain components within the bacterial cell wall. This disruption inhibits the growth and replication of M. tuberculosis, thus helping to eliminate the infection.

   Pyrazinamide is administered orally and is rapidly absorbed into the bloodstream. It is metabolized in the liver, and its major metabolite, pyrazinoic acid, is responsible for its antimycobacterial activity. The drug is generally well-tolerated, with common side effects including gastrointestinal disturbances, hepatotoxicity, and hyperuricemia (elevated levels of uric acid in the blood).

   It is important to note that pyrazinamide is often used in combination with other drugs, such as isoniazid and rifampin, to form a comprehensive treatment regimen for TB. This combination therapy helps to prevent the emergence of resistant strains and increases the efficacy of treatment.

   In conclusion, pyrazinamide is an antimycobacterial drug used primarily in the treatment of tuberculosis. It functions by inhibiting the growth and replication of M. tuberculosis, thereby aiding in the elimination of the infection.

Common Misspellings for PYRAZINAMIDE

• oyrazinamide
• lyrazinamide
• -yrazinamide
• 0yrazinamide
• ptrazinamide
• pgrazinamide
• phrazinamide
• purazinamide
• p7razinamide
• p6razinamide
• pyeazinamide
• pydazinamide
• pyfazinamide
• pytazinamide
• py5azinamide
• py4azinamide
• pyrzzinamide
• pyrszinamide
• pyrwzinamide
• pyrqzinamide

Etymology of PYRAZINAMIDE

The word "Pyrazinamide" is derived from the combination of two components: "Pyrazine" and "amide".

The term "Pyrazine" comes from the German word "Pyrazin", which was coined by the German chemist Rochleder in 1855. Rochleder derived the word from the combination of "pyra" (meaning "fire" in Greek) and "azin" (another chemical suffix). "Pyrazine" is a nitrogenous organic compound that consists of a benzene ring fused with a pyrazine ring.

The suffix "-amide" is derived from the Latin word "amid" or "amidum", which refers to a chemical compound formed by the replacement of the hydroxyl group (-OH) of an acid by the amino group (-NH2).