Psoralene is a naturally occurring organic compound that belongs to a class of compounds known as furanocoumarins. It can also be produced synthetically. Psoralene is commonly found in various plants, such as the Psoralea corylifolia and Ammi majus, and can be extracted from their seeds, fruits, or roots.
Psoralene is well-known for its ability to react with ultraviolet (UV) light. It acts as a photosensitizer, meaning it enhances the skin's sensitivity to UV light when it comes into contact with it. This property makes psoralene a crucial component in a treatment procedure called psoralen plus ultraviolet A (PUVA) therapy, which is used to treat certain skin disorders like psoriasis, vitiligo, and cutaneous T-cell lymphoma.
In PUVA therapy, psoralene is either applied topically or ingested orally before the patient's skin is exposed to artificial UVA rays or natural sunlight. The combination of psoralene and UVA light helps in reducing the abnormally rapid growth of skin cells, suppressing the immune system, and promoting pigmentation in areas affected by vitiligo.
It is important to note that psoralene can cause skin photosensitivity, and individuals undergoing PUVA therapy should protect their skin from additional sun exposure for a specified period to prevent adverse reactions like sunburns or rashes.
Outside of its medical uses, psoralene also has other applications, including as a component in cosmetics, perfumes, and insecticides. Additionally, it has been researched for its potential as an anticancer and antimicrobial agent due to its unique chemical properties.
Overall, psoralene is a compound that plays a crucial role in PUVA therapy and serves as a
