Porokeratosis palmaris et plantaris disseminata (PPPD) is a rare inherited skin disorder characterized by the presence of multiple small, round, or oval-shaped patches on the palms, soles, or other parts of the body. It belongs to a group of skin conditions called porokeratoses.
The term "porokeratosis" refers to the formation of a specific type of skin lesion known as a porokeratotic plaque. These plaques are raised, well-defined, and have a distinctive border surrounding a central depression. The plaques are usually brown or red in color and may be scaly, rough, or have a warty appearance.
PPPD is unique because it primarily affects the palms and soles, although some patients may also develop lesions on other parts of the body, including the trunk, extremities, and face. The condition usually appears during childhood or adolescence, but can also present in later years. PPPD does not cause any significant symptoms or health complications, and the lesions are generally considered to be benign. However, they can cause cosmetic concerns due to their appearance.
The exact cause of PPPD is still unknown, but it is believed to have a genetic basis. It is inherited in an autosomal dominant manner, meaning that an affected individual has a 50% chance of passing the condition onto their offspring. Diagnosis of PPPD is typically made through clinical examination and confirmed by skin biopsy.
While there is no cure for PPPD, treatment options are available to manage the symptoms and reduce the appearance of the lesions. These may include the use of topical creams, cryotherapy, laser therapy, or surgical excision. Regular follow-up and monitoring are important for individuals with PPPD, as they may be at a slightly increased risk of developing
