Porokeratosis of Mibelli is a rare, chronic skin disorder characterized by the development of distinct skin lesions known as porokeratotic keratoses. It is named after Vittorio Mibelli, the Italian dermatologist who first described the condition. Porokeratotic keratoses are annular (ring-shaped) patches of thickened skin that typically have a central depression, giving them a distinctive appearance.
This condition is believed to be of genetic origin, although the exact cause is still not fully understood. It typically manifests during childhood or adolescence and tends to persist throughout adulthood. The lesions most commonly appear on the hands and feet, particularly the palms and soles, but they can also occur on other areas of the body.
The characteristic feature of Porokeratosis of Mibelli is the presence of a raised border surrounding a depressed center within the skin lesions. The keratinocytes, the outermost layer of skin cells, in the border exhibit abnormal growth patterns and this can cause the thickening and hardening of the skin. These lesions can be asymptomatic or may cause itching, burning, or discomfort. Occasionally, they can become inflamed or infected.
Although Porokeratosis of Mibelli is a chronic condition without a cure, management strategies can be employed to minimize symptoms and prevent lesions from worsening. Treatment options often focus on reducing the thickness of the lesions and controlling symptoms. These may include topical retinoids, cryotherapy, laser therapy, topical corticosteroids, or keratolytic agents. In severe cases, surgical removal of the lesions may be necessary.
Regular monitoring by a dermatologist is essential to track the progression of the condition and to address any complications that may arise.
