How Do You Spell POLYIMMUNOGLOBULIN RECEPTOR?

Pronunciation: [pˌɒlɪˈɪmənˌɒɡləbjˌʊlɪn ɹɪsˈɛptə] (IPA)

Polyimmunoglobulin Receptor is a complex term in immunology that refers to a receptor for the transport of immunoglobulins across the epithelial barrier. The IPA phonetic transcription for this word can be broken down into /pɒliˌɪmjʊnəʊˈɡləʊbjuːlɪn rɪsɛptə/. The term contains a total of 25 letters, consisting of four syllables, and is noted for its complexity in pronunciation and spelling. Proper understanding and use of the Polyimmunoglobulin Receptor can aid in the diagnosis and management of immunological disorders.

POLYIMMUNOGLOBULIN RECEPTOR Meaning and Definition

1. The polyimmunoglobulin receptor (pIgR) is a transmembrane protein that plays a crucial role in the transport of immunoglobulins across epithelial cells. It is primarily found in mucosal tissues, such as the respiratory, intestinal, and genitourinary tracts, where it aids in the secretion of antibodies to protect against invading pathogens.

   The structure of pIgR consists of an extracellular region, a transmembrane domain, and a cytoplasmic tail. The extracellular portion contains several immunoglobulin-like domains that are responsible for binding and internalizing immunoglobulins. The binding of pIgR to certain immunoglobulin classes, particularly dimeric IgA and pentameric IgM, triggers their transcytosis across the epithelial cells.

   Once the immunoglobulin is bound to pIgR on the basolateral side of the epithelial cell, it is internalized through receptor-mediated endocytosis. The pIgR-antibody complex is then transported through the cell and released on the apical side, where the antibodies can then function in the mucosal environment.

   The role of pIgR is crucial in the defense against pathogens, as it allows for the production of secretory immunoglobulins that can neutralize and eliminate them. Additionally, pIgR also plays a role in immune regulation and maintaining homeostasis in mucosal tissues.

   In summary, the polyimmunoglobulin receptor is a transmembrane protein that facilitates the transport of certain immunoglobulin classes across epithelial cells, thereby aiding in the mucosal immune defense against pathogens.

Common Misspellings for POLYIMMUNOGLOBULIN RECEPTOR

• oolyimmunoglobulin receptor
• lolyimmunoglobulin receptor
• -olyimmunoglobulin receptor
• 0olyimmunoglobulin receptor
• pilyimmunoglobulin receptor
• pklyimmunoglobulin receptor
• pllyimmunoglobulin receptor
• pplyimmunoglobulin receptor
• p0lyimmunoglobulin receptor
• p9lyimmunoglobulin receptor
• pokyimmunoglobulin receptor
• popyimmunoglobulin receptor
• pooyimmunoglobulin receptor
• poltimmunoglobulin receptor
• polgimmunoglobulin receptor
• polhimmunoglobulin receptor
• poluimmunoglobulin receptor
• pol7immunoglobulin receptor
• pol6immunoglobulin receptor
• polyummunoglobulin receptor

Etymology of POLYIMMUNOGLOBULIN RECEPTOR

The word "Polyimmunoglobulin Receptor" is a compound term that combines several roots and suffixes:

1. Poly-: Derived from the Greek word "polys", meaning "many" or "multiple". In scientific terminology, "poly-" is often used to indicate multiple or many.

2. Immunoglobulin: It is a combination of "immune" and "globulin". "Immune" is derived from the Latin word "immunis", meaning "exempt" or "protected". "Globulin" refers to a type of protein found in the blood plasma. Immunoglobulins, also known as antibodies, are specialized proteins produced by the immune system in response to foreign substances (antigens).

3. Receptor: Derived from the Latin word "recipere", meaning "to receive".