POLYDEOXYRIBONUCLEOTIDE LIGASES Meaning and
Definition
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Polydeoxyribonucleotide ligases are enzymes that play a crucial role in the process of DNA replication and repair. They are responsible for joining together the individual units of deoxyribonucleotides, known as nucleotides, in a sequence-specific manner to form a complete DNA strand. These enzymes are essential for maintaining the integrity and stability of the DNA molecule.
Polydeoxyribonucleotide ligases are involved in various cellular processes such as DNA replication, DNA repair, DNA recombination, and DNA modification. In DNA replication, these enzymes facilitate the joining of short DNA fragments called Okazaki fragments, which are synthesized on the lagging strand during DNA synthesis. They also play a crucial role in the repair of damaged DNA by catalyzing the rejoining of broken DNA strands.
The process of ligase action involves the formation of a phosphodiester bond between the 3' hydroxyl group of one nucleotide and the 5' phosphate group of another nucleotide. This reaction requires the presence of adenosine triphosphate (ATP) as a cofactor to provide the necessary energy for the ligation process.
Polydeoxyribonucleotide ligases are highly specific enzymes that recognize and bind to the DNA ends, ensuring accurate joining of the nucleotides. They are essential for maintaining genomic stability and integrity by providing an efficient and precise mechanism for DNA replication and repair.
Common Misspellings for POLYDEOXYRIBONUCLEOTIDE LIGASES
- oolydeoxyribonucleotide ligases
- lolydeoxyribonucleotide ligases
- -olydeoxyribonucleotide ligases
- 0olydeoxyribonucleotide ligases
- pilydeoxyribonucleotide ligases
- pklydeoxyribonucleotide ligases
- pllydeoxyribonucleotide ligases
- pplydeoxyribonucleotide ligases
- p0lydeoxyribonucleotide ligases
- p9lydeoxyribonucleotide ligases
- pokydeoxyribonucleotide ligases
- popydeoxyribonucleotide ligases
- pooydeoxyribonucleotide ligases
- poltdeoxyribonucleotide ligases
- polgdeoxyribonucleotide ligases
- polhdeoxyribonucleotide ligases
- poludeoxyribonucleotide ligases
- pol7deoxyribonucleotide ligases
- pol6deoxyribonucleotide ligases
- polyseoxyribonucleotide ligases
Etymology of POLYDEOXYRIBONUCLEOTIDE LIGASES
The word "Polydeoxyribonucleotide Ligases" can be broken down into its components to understand its etymology:
1. Polydeoxyribonucleotide: "Poly" means many or multiple, "deoxyribo" refers to deoxyribonucleic acid (DNA), and "nucleotide" refers to the building blocks of DNA. Therefore, "polydeoxyribonucleotide" indicates multiple units of DNA building blocks.
2. Ligase: "Ligase" is derived from the Latin word "ligare", which means "to bind". In biological terms, a ligase is an enzyme involved in joining DNA fragments together by catalyzing the formation of a phosphodiester bond between them.
