Parathyroid cancers are extremely rare malignant tumors that develop in the parathyroid glands. The correct spelling of "parathyroid" is /ˌpærəˈθaɪrɔɪd/ ("PAR-uh-thy-roid"), with the stress on the second syllable. The word is comprised of three morphemes: "para-" meaning "beside," "thyroid" referring to the gland, and the suffix "-oid" meaning "resembling." Thus, "parathyroid" means "beside the thyroid," as the parathyroid glands are four small, pea-sized glands located behind the thyroid gland. Early detection and treatment are critical for better outcomes in parathyroid cancers.
Parathyroid cancers refer to malignant growths that develop in the parathyroid glands, which are small endocrine glands located near the thyroid gland in the neck. These cancers are extremely rare, accounting for less than 1% of all cases related to cancers of the endocrine system.
The parathyroid glands are responsible for producing and regulating the levels of parathyroid hormone (PTH), which plays a crucial role in maintaining calcium and phosphate balance in the body. Parathyroid cancers disrupt the normal function of these glands by causing an overproduction of PTH, leading to abnormally high levels of calcium in the blood, a condition known as hypercalcemia.
The exact cause of parathyroid cancers is not well understood and often unknown. However, certain genetic conditions such as multiple endocrine neoplasia type 1 (MEN1) and familial isolated hyperparathyroidism (FIHP) have been associated with an increased risk of developing parathyroid cancers.
Symptoms of parathyroid cancers can vary, but may include fatigue, weakness, kidney stones, frequent urination, bone pain, and fractures. Diagnosis typically involves a series of tests such as blood tests to measure calcium and PTH levels, imaging studies like ultrasounds, CT scans, or MRIs, and a biopsy to confirm the presence of cancerous cells.
Treatment options for parathyroid cancers may involve surgery to remove the affected parathyroid glands, and in some cases, the nearby lymph nodes may also be removed. Radiation therapy and chemotherapy may be recommended in more advanced cases. Regular monitoring and follow-up care are essential in managing parathyroid cancers due to the high risk of recurrence.
The etymology of the word "parathyroid cancers" is as follows:
1. Parathyroid: The word "parathyroid" is derived from Greek. "Para-" means "beside" or "alongside", and "thyreo-" refers to the thyroid gland. Therefore, "parathyroid" essentially means "beside the thyroid". The term was coined by the German anatomist Friedrich Albert von Zenker in 1870.
2. Cancers: The term "cancers" comes from the Latin word "cancer", which originally meant "crab". This term was used as early as the 5th century BC by the Greek physician Hippocrates to describe tumors and their spreading growth, which he believed resembled a crab's legs. Over time, "cancer" evolved to specifically refer to malignant tumors and the disease of cancer.