P NPPASE Meaning and
Definition
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p NPPase, also known as plasma membrane calcium ATPase, refers to a protein enzyme that plays a crucial role in maintaining the calcium homeostasis of the plasma membrane in various cells. It belongs to the P-type ATPase family and is classified as an integral membrane protein. The acronym "p NPPase" stands for paranuclear Na+-K+-ATPase.
The primary function of p NPPase is to actively transport calcium ions out of the cytoplasm and into the extracellular space against their concentration gradient, using energy derived from the hydrolysis of ATP. By doing so, it helps in regulating the intracellular calcium levels, which are vital for numerous cellular processes such as muscle contraction, nerve signal transmission, and cell differentiation.
p NPPase is mainly localized on the plasma membrane, where it interacts with calcium ions and transports them out of the cell. It is also present in other cellular compartments, including the Golgi apparatus and endoplasmic reticulum, aiding in maintaining calcium balance within these organelles.
Mutations or dysregulation of p NPPase expression can lead to various disorders such as neurodegenerative diseases, cardiac abnormalities, and immune system dysfunction. Therefore, p NPPase is an essential protein involved in the maintenance of cellular calcium homeostasis and overall cell function.
Common Misspellings for P NPPASE
Etymology of P NPPASE
The term "pNPPase" is an abbreviation for "para-nitrophenylphosphatase".
The etymology of this term can be broken down as follows:
- "Para-" is a prefix derived from the Greek word "pará" meaning "beside" or "beyond". In chemistry, "para-" typically denotes a substitution pattern in aromatic compounds where the substituents are positioned opposite to each other.
- "Nitro-" is a prefix derived from the Latin word "nitrum", referring to "saltpetre" or "potassium nitrate". In organic chemistry, "nitro-" indicates the presence of a nitro group (-NO2), which consists of a nitrogen atom bonded to two oxygen atoms.
- "Phenyl" originates from the Latin word "phenum" meaning "distillate of coal tar".
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