Oxidized LDL cholesterol is a type of cholesterol that has undergone oxidation, making it more harmful to the body. The word 'oxidized' is pronounced /ˈɑːksɪdaɪzd/ (ahk-si-dized), and refers to the chemical reaction that occurs when LDL cholesterol comes into contact with oxygen. 'LDL' is pronounced /ɛl di ɛl/ (el dee el) and stands for low-density lipoprotein, a type of cholesterol that carries cholesterol molecules around the body. The whole term is pronounced /ˈɑːksɪdaɪzd ˈɛldiːɛl kəˈlɛstərɒl/ (ahk-si-dized el-dee-el kuh-les-tuh-rol).
Oxidized LDL cholesterol refers to low-density lipoprotein (LDL) cholesterol that has undergone oxidation in the body. LDL cholesterol is a type of cholesterol that carries cholesterol molecules from the liver to cells in the body for various functions. However, when LDL cholesterol is exposed to oxidative stress, typically in the form of free radicals, it becomes oxidized.
Oxidation is a chemical process that involves the loss of electrons from a substance, and in the case of LDL cholesterol, it leads to a structural change in the molecule. This oxidized form of LDL cholesterol is believed to be more harmful than non-oxidized LDL cholesterol because it can promote inflammation and contribute to the development and progression of atherosclerosis, a condition characterized by the buildup of plaque in the arteries.
When LDL cholesterol becomes oxidized, it can trigger an inflammatory response in the lining of the arteries. This response leads to the recruitment of immune cells that attempt to clear the oxidized LDL from the artery walls. However, this process can result in the formation of foam cells, which are a hallmark of early atherosclerosis.
Therefore, the presence of oxidized LDL cholesterol is considered an important risk factor for cardiovascular diseases, including heart attacks and strokes. Measurement of oxidized LDL cholesterol levels can provide valuable information regarding oxidative stress and the risk of developing cardiovascular complications. It is often recommended to reduce the levels of oxidized LDL cholesterol through lifestyle modifications, such as adopting a healthy diet, engaging in regular physical activity, and avoiding smoking and excessive alcohol consumption.