Osteitis Fibrosa Disseminata is a medical condition characterized by the abnormal breakdown of bone tissue and its replacement with fibrous connective tissue. It is also referred to as Von Recklinghausen disease of bone or osteitis fibrosa cystica.
In this condition, excessive parathyroid hormone (PTH) is released due to overactivity of the parathyroid glands, leading to increased bone resorption and the formation of cyst-like areas within the bone. These cysts are filled with fibrous tissue, which gradually replaces the normal bone structure. As a result, the affected bones become weak, fragile, and prone to fractures.
Osteitis Fibrosa Disseminata is primarily caused by an underlying condition called primary hyperparathyroidism, usually due to a benign tumor in one or more of the parathyroid glands. The excessive PTH production disrupts the balance of calcium and phosphorus in the body, leading to increased levels of calcium in the blood.
Common symptoms of Osteitis Fibrosa Disseminata include bone pain, frequent fractures, and deformities. Other signs may include fatigue, muscle weakness, kidney stones, and changes in mood or cognitive function.
Treatment for Osteitis Fibrosa Disseminata focuses on addressing the underlying primary hyperparathyroidism through surgical removal of the affected parathyroid gland. Calcium and vitamin D supplements may be prescribed to help maintain proper bone health. In severe cases, additional medications may be used to regulate calcium levels in the blood. Regular monitoring and follow-up with a healthcare professional are crucial to prevent further bone loss and manage the condition effectively.
