Opsonize (/ˈɒpsənaɪz/) is a term used in immunology to describe the process of enhancing phagocytosis, which occurs when pathogens are marked for destruction by immune cells. The word is derived from the Greek word "opson", meaning "to prepare a feast". The spelling of "opsonize" is phonetically accurate, as the "s" between the vowels is pronounced as a "z". Proper pronunciation is essential to avoid confusion with similar sounding words, such as "oxidize" or "optionize".
Opsonize is a verb that refers to the process in which a substance, typically an antibody or complement protein, coats the surface of a pathogen or foreign particle, facilitating its recognition and uptake by immune cells. This opsonization process enhances the ability of immune cells, especially phagocytes such as macrophages and neutrophils, to effectively engulf and destroy the opsonized target.
During opsonization, antibodies or complement proteins bind to specific epitopes on the surface of the pathogen or particle. This binding not only marks the target for recognition by immune cells but also triggers various immune responses that aid in the elimination of the invader. Opsonization enhances phagocytosis by promoting the attachment of immune cells to the opsonized particles through cell surface receptors, such as Fc receptors or complement receptors.
Opsonization plays a crucial role in host defense against pathogens and other foreign substances. By facilitating the recognition and clearance of pathogens, opsonization contributes to the overall effectiveness of the immune response. Additionally, opsonization can help initiate and regulate subsequent immune responses, such as inflammation and activation of the complement system.
In summary, opsonize refers to the process of coating pathogens or foreign particles with substances like antibodies or complement proteins, enhancing their recognition and uptake by immune cells for subsequent destruction and elimination.
To prepare for phagocytosis, noting the action of opsonins upon microorganisms.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "opsonize" has its etymology rooted in the Greek language. It comes from the Greek verb "opsono" (ὀψώνομαι), meaning "I buy provisions" or "I prepare food". In ancient Greece, opson was used to refer to a condiment or seasoning that was added to food in order to enhance its flavor. Over time, the term "opsonize" was adopted in the field of immunology to describe the process of coating or preparing a cell or particle for phagocytosis (engulfment) by immune cells, thus making it more enticing or appetizing for the immune system.