NGF RECEPTORS Meaning and
Definition
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NGF receptors, also known as nerve growth factor receptors, are a group of cell surface receptors that play a crucial role in the development, maturation, and survival of neurons. NGF receptors are specifically designed to bind to nerve growth factor (NGF), a protein that is secreted by target cells and acts as a survival and differentiation factor for nerve cells.
There are two main types of NGF receptors: the high-affinity receptor, TrkA, and the low-affinity receptor, p75NTR. TrkA is a receptor tyrosine kinase, meaning it activates intracellular signaling pathways upon binding to NGF. This leads to the activation of various downstream signaling molecules involved in neuronal development. On the other hand, p75NTR is a member of the tumor necrosis factor receptor superfamily and can bind to multiple ligands in addition to NGF.
The binding of NGF to its receptors triggers a cascade of events that promote the survival, differentiation, and growth of neurons. These events include the activation of intracellular signaling pathways such as the MAPK/ERK pathway and the PI3K/Akt pathway, which mediate cell survival, growth, and differentiation.
The dysregulation of NGF receptors or their downstream signaling pathways has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and various peripheral neuropathies. Therefore, NGF receptors represent potential therapeutic targets for the development of drugs aimed at promoting neuronal survival, regeneration, and repair.
Common Misspellings for NGF RECEPTORS
- mgf receptors
- jgf receptors
- hgf receptors
- nff receptors
- nvf receptors
- nbf receptors
- nhf receptors
- nyf receptors
- ntf receptors
- ngd receptors
- ngc receptors
- ngv receptors
- ngg receptors
- ngt receptors
- ngr receptors
- ngf eeceptors
- ngf deceptors
- ngf feceptors
- ngf teceptors
- ngf 5eceptors
Etymology of NGF RECEPTORS
The term "NGF receptors" is an acronym for "Nerve Growth Factor receptors". Let's break down the etymology of each component:
- Nerve: This word originated from the Latin word "nervus", meaning "sinew" or "nerve". It denotes the specialized fibers in the body responsible for transmitting electrical impulses.
- Growth: Derived from the Old English word "growan", meaning "to increase" or "to develop". It refers to the process of increasing in size or progressing in development.
- Factor: Derived from the Latin word "factorem", meaning "doer" or "maker". In science, it is used to describe a component or stimulus that plays a significant role in a particular process or phenomenon.
- Receptors: Derived from the Latin word "recipere", meaning "to receive".
