How Do You Spell NEUTRAL ENDOPEPTIDASE?

Pronunciation: [njˈuːtɹə͡l ˈɛndə͡ʊpˌɛptɪdˌe͡ɪs] (IPA)

Neutral Endopeptidase is an enzyme that plays a vital role in the breakdown of biologically active peptides. The spelling of "Neutral Endopeptidase" can be explained using the International Phonetic Alphabet (IPA). The word starts with the "n" sound, followed by the "yuh" sound for "eu," which is not a common sound in English. The "tr" and "al" sounds are pronounced distinctly, and the final "ase" is pronounced with a hard "a" sound. Overall, the IPA helps to clarify the correct spelling and pronunciation of this important scientific term.

NEUTRAL ENDOPEPTIDASE Meaning and Definition

1. Neutral endopeptidase, also known as neprilysin or neprilysin enzyme, is a type II transmembrane protein that plays a crucial role in the degradation of bioactive peptides. It is a zinc-dependent metallopeptidase enzyme that is widely distributed throughout the body, particularly in the kidney, lung, liver, and brain.

   Neutral endopeptidase functions by cleaving peptide bonds within the interior of the peptide sequence. It acts on a variety of different peptides involved in numerous physiological processes, including the regulation of blood pressure, inflammation, cell growth, and neurotransmitter activity. By breaking down these peptides, neutral endopeptidase helps maintain homeostasis in the body.

   In the cardiovascular system, neutral endopeptidase is involved in the regulation of blood pressure and fluid balance. This enzyme degrades natriuretic peptides like atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which signal the body to decrease blood volume and pressure. By reducing the levels of these peptides, neutral endopeptidase indirectly increases sodium and water reabsorption, thereby maintaining blood pressure.

   Neutral endopeptidase has also been investigated for its potential therapeutic applications. Inhibitors of this enzyme have been developed as treatments for various conditions, including heart failure, hypertension, and Alzheimer's disease. By inhibiting neutral endopeptidase, the degradation of bioactive peptides is slowed down, leading to increased peptide levels and potentially beneficial effects on disease pathology.

   In summary, neutral endopeptidase is a zinc-dependent metallopeptidase enzyme involved in the cleavage of bioactive peptides. Its multifunctional nature and widespread distribution make it a crucial component of several

Common Misspellings for NEUTRAL ENDOPEPTIDASE

• beutral endopeptidase
• meutral endopeptidase
• jeutral endopeptidase
• heutral endopeptidase
• nwutral endopeptidase
• nsutral endopeptidase
• ndutral endopeptidase
• nrutral endopeptidase
• n4utral endopeptidase
• n3utral endopeptidase
• neytral endopeptidase
• nehtral endopeptidase
• nejtral endopeptidase
• neitral endopeptidase
• ne8tral endopeptidase
• ne7tral endopeptidase
• neurral endopeptidase
• neufral endopeptidase
• neugral endopeptidase
• neuyral endopeptidase

Etymology of NEUTRAL ENDOPEPTIDASE

The word "Neutral Endopeptidase" is derived from several sources:

1. Neutral: The term "neutral" originates from the Latin neuter, which means "neither" or "neuter". In the context of "neutral endopeptidase", it refers to the enzyme's ability to function within a neutral pH environment.

2. Endo-: This prefix is derived from the Greek word "endon", which means "inside" or "within". In "neutral endopeptidase", it indicates that the enzyme is involved in cleaving peptide bonds within the peptide chain.

3. Peptidase: The suffix "-ase" is used to denote an enzyme. The term "peptidase" comes from the Greek word "peptos", meaning "digested", and the suffix "-ase". It refers to any enzyme that catalyzes the hydrolysis of peptides into amino acids.