Neuritic atrophy is a medical condition where there is a degeneration or wasting of the nerve fibers called neurites. The spelling of this word can be explained using IPA phonetic transcription as [njuːˈrɪtɪk ˈætrəfi]. The first syllable is pronounced as "nju" as in "new", followed by "rɪ" as in "ripple". The next syllable is pronounced as "tɪk" as in "tic-tac-toe", and the final syllable is spelled as "ætrəfi" with a silent "h" but pronounced as "æ" as in "cat" and "fɪ" as in "finish."
Neuritic atrophy, also known as neuronal atrophy or neural degeneration, refers to the pathological process characterized by the shrinking or loss of nerve cells (neurons) within the nervous system. It involves the progressive deterioration and structural changes of neuronal structures such as axons, dendrites, and synapses.
This condition can occur in various regions of the nervous system, including the brain, spinal cord, and peripheral nerves. Neuritic atrophy often manifests as a result of neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis (ALS).
The structural changes associated with neuritic atrophy include the loss of dendritic branches, shortening or retraction of axonal fibers, and the degeneration of synaptic connections. These alterations ultimately lead to a decrease in the overall size and function of affected neurons.
The consequences of neuritic atrophy can vary depending on the location and extent of the degeneration. It can result in cognitive decline, motor and sensory impairments, memory loss, muscular weakness or atrophy, and even paralysis in severe cases.
Although neuritic atrophy is often a natural consequence of aging, it can also occur due to various pathological factors such as genetic mutations, toxins, infections, or metabolic imbalances. Understanding the mechanisms underlying this process is crucial for the development of potential therapeutic strategies to prevent or delay neuronal degeneration and alleviate the associated symptoms.
Muscular a. due to neuritis or degeneration of the nerves, beginning usually in the lower extremities.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "neuritic" is derived from the noun "neurite", which refers to a thin prolongation or extension from a nerve cell (neuron). It originates from the Greek word "neuron" meaning "nerve". "Neuritic" describes anything related to or affecting the neurites or nerve fibers.
The word "atrophy" comes from the Greek word "atrophos", meaning "without nourishment" or "wasting away". It refers to the gradual degeneration or decrease in size or function of an organ or tissue, often due to lack of use or insufficient blood supply.
Therefore, "neuritic atrophy" describes the degeneration or wasting away of nerve fibers or neurites.