The spelling of the word "most obloquious" can be a bit tricky. The IPA phonetic transcription for this word is /məʊst əˈbləʊkwiəs/. The first syllable is pronounced as "mohst" with the "o" sound like in "low". The second syllable is pronounced as "uh-BLOH-kwee-uhs". The "o" sound in "obloquious" is like in "not" and "hot", while the "u" sound is like in "pull". Overall, "most obloquious" means extremely critical or harsh in speech or action.