MINK CELL FOCUS INDUCING VIRUSES Meaning and
Definition
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Mink Cell Focus Inducing Viruses (MCF) are a type of retrovirus that primarily infects minks, a species of aquatic mammals belonging to the mustelid family. These viruses are known to induce the formation of focal cells, or Mink Cell Foci (MCF), which are clumps of infected cells that have undergone abnormal growth and differentiation.
MCF viruses are characterized by their ability to integrate their genetic material into the DNA of host cells, utilizing the reverse transcriptase enzyme to perform reverse transcription of their single-stranded RNA genome into DNA. This DNA is then integrated into the host cell's genome, leading to the production of viral proteins and subsequent viral replication.
MCF viruses have been associated with various pathological conditions in minks, including fibrosarcomas, lymphomas, and other neoplastic diseases. The induction of cellular transformation by these viruses is believed to be a result of the integration of viral genes into the host cell's genome, leading to the dysregulation of cellular growth and division.
In addition to minks, MCF viruses have also been found to infect other mustelid species such as ferrets and weasels. The transmission of these viruses usually occurs through direct contact with infected bodily fluids or inhalation of contaminated aerosols.
Understanding the biology and pathogenicity of MCF viruses is important not only for the health and well-being of mink populations but also for the potential zoonotic implications and socioeconomic impact, particularly in regions where mink farming is prevalent.
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