MALONDIALDEHYDE Meaning and
Definition
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Malondialdehyde, often abbreviated as MDA, is a highly reactive organic compound formed as a byproduct of polyunsaturated fatty acid peroxidation. It is derived from the breakdown of lipid peroxides, which are generated during oxidative stress or damage to cell membranes.
MDA is a small molecule with a molecular weight of 72.06 g/mol. It possesses a reactive carbonyl group, making it a reactive aldehyde compound. Being highly reactive, malondialdehyde can form covalent adducts with numerous molecules, including DNA, proteins, and lipids. This reactivity has garnered significant attention in biomedical research, particularly in oxidative stress studies.
The quantification of malondialdehyde levels serves as a marker for lipid peroxidation and oxidative stress, as its increased presence indicates cellular damage. Researchers utilize various methods, such as spectrophotometry or high-performance liquid chromatography, to measure MDA levels in biological samples.
Elevated levels of malondialdehyde have been associated with various pathological conditions, including cardiovascular diseases, neurodegenerative disorders, and cancer. Moreover, MDA has shown to contribute to the formation of advanced glycation end products (AGEs), which are implicated in aging and diabetic complications.
Overall, malondialdehyde plays a crucial role in assessing oxidative stress levels and understanding the pathophysiology of several diseases. Its reactivity and ability to form adducts with biomolecules make it a significant focus of research in the field of oxidative stress and related disorders.
Common Misspellings for MALONDIALDEHYDE
- nalondialdehyde
- kalondialdehyde
- jalondialdehyde
- mzlondialdehyde
- mslondialdehyde
- mwlondialdehyde
- mqlondialdehyde
- makondialdehyde
- mapondialdehyde
- maoondialdehyde
- malindialdehyde
- malkndialdehyde
- mallndialdehyde
- malpndialdehyde
- mal0ndialdehyde
- mal9ndialdehyde
- malobdialdehyde
- malomdialdehyde
- malojdialdehyde
- malohdialdehyde
Etymology of MALONDIALDEHYDE
The word "malondialdehyde" is derived from the combination of the terms "malonic acid" and "dialdehyde". Here's the breakdown:
1. Malonic acid: The term "malonic" comes from the Latin word "malum" meaning "apple". The Latin word "malonicus" referred to something related to apples. It was named so because malonic acid was first isolated from apple juice by German chemist Justus von Liebig in 1858.
2. Dialdehyde: The term "dialdehyde" is a combination of the prefix "di-" meaning "two" and the word "aldehyde". "Aldehyde" originates from the Latin word "alcohol dehydrogenatus", meaning "dehydrogenated alcohol". It refers to a chemical compound containing the -CHO functional group.
