The word "Lurcher Mice" is spelled with the IPA phonetic transcription /ˈlɜːtʃəmaɪs/. The first syllable "Lur" is pronounced with the sound of the letter "er" and the "u" sound put together (like in the word "fur"). The second syllable "cher" is pronounced with the sound of "ch" and the letter "er" (like in the word "merchant"). The last syllable "Mice" is pronounced with the long "i" sound, as in "ice". So, the pronunciation of "Lurcher Mice" is "Lur-cher My-s".
Lurcher mice refer to a specific strain or type of laboratory mice that possess particular genetic attributes. These mice are commonly used in scientific research and experimentation in various fields including genetics, neurobiology, and pharmacology. The term "Lurcher" specifically indicates a genetic mutation found in these mice that affects their cerebellum, the region of the brain predominantly responsible for coordinating movement and balance.
The Lurcher mutation is characterized by the loss or significant reduction in the number of Purkinje cells within the cerebellum. Purkinje cells are specialized neurons that play a critical role in regulating motor coordination, learning, and fine motor control. Due to this genetic abnormality, Lurcher mice display an ataxic phenotype, meaning they exhibit uncoordinated and jerky movements, impaired balance, and an overall lack of motor control.
The study of Lurcher mice has been instrumental in understanding the functional importance of the cerebellum in motor coordination and balance. These mice have further served as valuable animal models for investigating various neurological disorders such as ataxia, cerebellar degeneration, and motor coordination impairments. By examining the behavior and physiological characteristics of Lurcher mice, researchers gain valuable insights into the mechanisms underlying these conditions, potentially leading to the development of new therapeutic approaches and treatments for related human disorders.
The term "Lurcher Mice" does not have a specific etymology as it is a combination of two separate words.
1. Lurcher: The word "lurcher" originated from the Middle English word "lourchen" which means "to lurk" or "to lie in wait". It was originally used to refer to a dog breed that was bred for hunting and poaching during the medieval period in Europe. The term later evolved to refer to any mixed-breed dog used for hunting.
2. Mice: The word "mice" originated from the Old English word "mys" or "mysse", which is the plural form of "mus" meaning "mouse". The term has remained relatively unchanged over the years and continues to refer to small rodents of the Muridae family.