LIPOAMIDE DEHYDROGENASE Meaning and
Definition
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Lipoamide dehydrogenase is an enzyme that plays a crucial role in cellular metabolism, particularly in the process of energy production. It belongs to a class of enzymes called oxidoreductases, which facilitate the transfer of electrons from one molecule to another.
Lipoamide dehydrogenase is involved in the oxidative decarboxylation of alpha-keto acids, such as pyruvate and alpha-ketoglutarate, which occur in the mitochondria of cells. During this process, the enzyme catalyzes the transfer of electrons from the lipoamide cofactor to nicotinamide adenine dinucleotide (NAD+), resulting in the generation of reduced NADH and a high-energy thioester intermediate.
The enzyme is typically found in multi-enzyme complexes called pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase complex, which are key components of the citric acid cycle and crucial for the breakdown of carbohydrates and amino acids. Lipoamide dehydrogenase acts as a regulatory component in these complexes, controlling the flow of electrons and ensuring efficient energy production.
Deficiencies or malfunctions in lipoamide dehydrogenase can lead to metabolic disorders, such as pyruvate dehydrogenase complex deficiency and alpha-ketoglutarate dehydrogenase deficiency, which are characterized by impaired energy production and a buildup of toxic metabolites. These conditions can result in various symptoms, including neurological abnormalities, developmental delays, and muscle weakness.
In summary, lipoamide dehydrogenase is an essential enzyme involved in energy metabolism, playing a critical role in the transfer of electrons and the generation of NADH. Its proper functioning is crucial for maintaining cellular energy homeostasis and preventing metabolic
Common Misspellings for LIPOAMIDE DEHYDROGENASE
- kipoamide dehydrogenase
- pipoamide dehydrogenase
- oipoamide dehydrogenase
- lupoamide dehydrogenase
- ljpoamide dehydrogenase
- lkpoamide dehydrogenase
- lopoamide dehydrogenase
- l9poamide dehydrogenase
- l8poamide dehydrogenase
- liooamide dehydrogenase
- liloamide dehydrogenase
- li-oamide dehydrogenase
- li0oamide dehydrogenase
- lipiamide dehydrogenase
- lipkamide dehydrogenase
- liplamide dehydrogenase
- lippamide dehydrogenase
- lip0amide dehydrogenase
- lip9amide dehydrogenase
- lipozmide dehydrogenase
Etymology of LIPOAMIDE DEHYDROGENASE
The word "lipoamide dehydrogenase" is derived from the combination of several terms:
1. Lipoamide: It originated from the Greek word "lipo" meaning "fat" or "lipid" and the suffix "-amide", which denotes a compound derived from ammonia. Lipoamide refers to a molecule that consists of a lipoic acid attached to an amine group.
2. Dehydrogenase: It is derived from the prefix "dehydro-" meaning "removal of hydrogen" and the suffix "-genase", which refers to an enzyme that catalyzes a reaction involving hydrogen transfer. Dehydrogenases are a class of enzymes that facilitate the transfer of hydrogen atoms from a substrate to an electron carrier.
Therefore, "lipoamide dehydrogenase" can be understood as an enzyme responsible for catalyzing a reaction involving the transfer of hydrogen atoms from lipoamide to an electron carrier.
