LINKAGE DISEQUILIBRIUMS Meaning and
Definition
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Linkage disequilibrium refers to the non-random association between two or more genetic loci or alleles within a population. It occurs when certain alleles or genetic variants at different loci are found together more often than would be expected by chance alone. Linkage disequilibrium is a measure of the genetic linkage or lack of recombination between two loci and is an outcome of their physical proximity on a chromosome.
In genetics, recombination occurs during the formation of eggs and sperm, leading to a shuffling of genetic material between homologous chromosomes. This process usually breaks down or reduces the correlation between different alleles at different loci, resulting in a random assortment. However, when recombination does not occur frequently enough or when certain genetic variants have a selective advantage, linkage disequilibrium may arise and persist in a population.
Linkage disequilibrium can have important implications in population genetics and genetic association studies. It can indicate genetic-relatedness between different loci, as well as provide insights into the evolutionary history and demographic processes of a population. Additionally, it has implications for identifying disease-causing genetic variants or performing genetic mapping studies, as variations closely linked to a disease-associated locus may be responsible for its inheritance.
Overall, linkage disequilibrium is a concept that helps to understand and quantify the non-random association of alleles or genetic variants and provides valuable information for various genetic studies and evolutionary analyses.
Common Misspellings for LINKAGE DISEQUILIBRIUMS
- kinkage disequilibriums
- pinkage disequilibriums
- oinkage disequilibriums
- lunkage disequilibriums
- ljnkage disequilibriums
- lknkage disequilibriums
- lonkage disequilibriums
- l9nkage disequilibriums
- l8nkage disequilibriums
- libkage disequilibriums
- limkage disequilibriums
- lijkage disequilibriums
- lihkage disequilibriums
- linjage disequilibriums
- linmage disequilibriums
- linlage disequilibriums
- linoage disequilibriums
- liniage disequilibriums
- linkzge disequilibriums
- linksge disequilibriums
Etymology of LINKAGE DISEQUILIBRIUMS
The term "Linkage Disequilibrium" (not "Linkage Disequilibriums") has its roots in the field of genetics.
The word "linkage" refers to the association or connection between two or more genes on the same chromosome. When genes are physically close to each other on a chromosome, they are said to be linked. This linkage can affect how they are inherited together.
The term "disequilibrium" suggests a departure from equilibrium or a deviation from the expected distribution of genetic variants within a population. In the context of genetics, it refers to the non-random association of alleles (alternative forms of a gene) at different loci (positions on a chromosome).
Therefore, "Linkage Disequilibrium" signifies the non-random association or deviation from the expected distribution of genetic variants between linked loci.
