LIGATION Meaning and
Definition
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Ligation is a term used in various scientific fields, particularly in biology, medicine, and chemistry. It refers to the process of joining or connecting two or more molecules, typically through the formation of a covalent bond, resulting in the creation of a larger and more complex molecule.
In molecular biology and genetics, ligation specifically refers to the joining of DNA fragments by the action of an enzyme known as DNA ligase. This process plays a crucial role in the construction of recombinant DNA molecules and in genetic engineering techniques such as cloning and gene manipulation. DNA ligase catalyzes the formation of a phosphodiester bond between the 3' end of one DNA fragment and the 5' end of another, effectively sealing the DNA strands together.
In medicine, ligation may also refer to the surgical procedure of tying off or closing a blood vessel or duct. This is commonly done to prevent bleeding or to block the flow of fluids in the body. For instance, the ligation of blood vessels during a surgical procedure can aid in controlling bleeding and reducing the risk of excessive blood loss.
Furthermore, in the field of organic chemistry, ligation may refer to the joining of two molecules using various chemical reactions, such as condensation reactions, to form a covalent bond. This allows for the creation of complex molecules and the synthesis of new compounds.
Overall, ligation is a versatile term that refers to the process of connecting molecules, whether it be in genetic engineering, surgical procedures, or chemical synthesis.
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The act of binding; the state of being bound.
Etymological and pronouncing dictionary of the English language. By Stormonth, James, Phelp, P. H. Published 1874.
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Other Common Misspellings for LIGATION
Etymology of LIGATION
The word "ligation" is derived from the Latin word "ligare", which means "to bind" or "to tie". It is formed from the noun "ligatio", meaning "a binding or tying". In English, "ligation" generally refers to the act or process of tying or binding, while in medical and biological contexts, it specifically refers to the process of joining two ends of a vessel or structure, typically through the use of sutures or clips.
Similar spelling words for LIGATION
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