LDLIC, also known as low-density lipoprotein-induced cytotoxicity, refers to the harmful effects caused by the oxidation of low-density lipoprotein (LDL) particles in the body.
LDL is a type of lipoprotein responsible for transporting cholesterol from the liver to the cells. However, when LDL particles become oxidized due to various factors such as smoking, high blood pressure, or diabetes, they can instigate LDLIC.
LDLIC is characterized by the disruption of cellular function and damage to the endothelial cells that line the blood vessels. The oxidized LDL particles tend to accumulate in the arterial walls, leading to the formation of atherosclerotic plaques, a key contributor to the development of cardiovascular diseases such as heart disease and stroke.
Furthermore, LDLIC triggers an inflammatory response within the blood vessels, attracting immune cells such as macrophages to the area. This accumulation of immune cells ultimately results in the formation of foam cells, a hallmark of atherosclerosis.
LDLIC is considered a critical step in the initiation and progression of atherosclerosis and is often used as a biomarker for assessing cardiovascular disease risk. Monitoring LDL levels and taking preventive measures, such as adopting a healthy diet, regular physical activity, and medication when necessary, can help mitigate the detrimental effects of LDLIC and reduce the risk of developing cardiovascular diseases.
