LCK KINASE Meaning and
Definition
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lck kinase is an enzyme belonging to the family of protein tyrosine kinases, specifically the Src family kinases. It plays a crucial role in signal transduction pathways involved in the regulation of immune system function and T-cell development. The protein is primarily expressed in T-cells, where it acts as a key regulator of T-cell receptor (TCR) signaling.
Lck kinase is responsible for phosphorylating tyrosine residues on various proteins in response to TCR activation. This phosphorylation event leads to the recruitment and activation of downstream effector molecules, initiating a cascade of signaling events that ultimately determine the fate and function of the T-cell.
The activity of lck kinase is tightly regulated to ensure proper T-cell activation and modulation of immune responses. It can be activated by the interaction between TCR and antigen-presenting cells, triggering a conformational change that exposes its active site for substrate binding and subsequent tyrosine phosphorylation.
Mutations in the lck kinase gene have been associated with various immunodeficiency disorders and autoimmune diseases, highlighting its critical role in maintaining immune homeostasis. Therapeutic targeting of lck kinase has emerged as a potential strategy for the treatment of certain immune disorders and cancers.
In summary, lck kinase is a protein tyrosine kinase primarily expressed in T-cells, involved in TCR signaling and immune system regulation. Its activity is crucial for proper T-cell function and the modulation of immune responses.
Common Misspellings for LCK KINASE
- kck kinase
- pck kinase
- ock kinase
- lxk kinase
- lvk kinase
- lfk kinase
- ldk kinase
- lcj kinase
- lcm kinase
- lcl kinase
- lco kinase
- lci kinase
- lck jinase
- lck minase
- lck linase
- lck oinase
- lck iinase
- lck kunase
- lck kjnase
- lck kknase
Etymology of LCK KINASE
The term "lck kinase" is derived from the combination of two components: "lck" and "kinase".
The "lck" component refers to lymphocyte-specific protein tyrosine kinase, which is a specific type of protein kinase predominantly found in T-cells. The abbreviation "lck" is derived from the term "lymphocyte cell kinase", which was initially used to describe this protein.
The term "kinase" is a general suffix used to describe an enzyme that catalyzes the transfer of a phosphate group from ATP (Adenosine Triphosphate) to a specific substrate molecule. The word "kinase" itself originates from the Greek word "kinein", meaning "to move".
Therefore, when combined, "lck kinase" refers to the lymphocyte-specific protein tyrosine kinase enzyme that plays a crucial role in signal transduction pathways within T-cells.
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