LARGE T ANTIGEN Meaning and
Definition
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Large T antigen is a protein molecule that plays a crucial role in the replication of certain DNA viruses, particularly those belonging to the polyomavirus family. It is named "large" due to its relatively high molecular weight compared to other antigens. Large T antigen is encoded by the early gene region of the virus genome and is expressed during the early stages of viral infection.
Functionally, large T antigen primarily functions as a DNA helicase and ATPase enzyme, which are essential for viral DNA replication. It unwinds the double-stranded DNA and separates the DNA strands, thus enabling the viral genome to be replicated. Large T antigen also has the ability to bind to various cellular proteins, including tumor suppressor proteins such as p53 and retinoblastoma protein (Rb). By binding and inactivating these proteins, large T antigen assists in the disruption of cell cycle regulation, allowing infected cells to continue dividing and supporting viral replication.
Moreover, large T antigen possesses transforming abilities, meaning it can cause uncontrolled cell growth and ultimately result in cellular transformation and tumorigenesis. This oncogenic potential is attributed to its interactions with various intracellular signaling pathways, modulating cell survival, proliferation, and differentiation.
Overall, the presence and activities of large T antigen have significant implications for viral replication, cellular transformation, and the pathogenesis of diseases associated with polyomaviruses.
Common Misspellings for LARGE T ANTIGEN
- karge t antigen
- parge t antigen
- oarge t antigen
- lzrge t antigen
- lsrge t antigen
- lwrge t antigen
- lqrge t antigen
- laege t antigen
- ladge t antigen
- lafge t antigen
- latge t antigen
- la5ge t antigen
- la4ge t antigen
- larfe t antigen
- larve t antigen
- larbe t antigen
- larhe t antigen
- larye t antigen
- larte t antigen
- largw t antigen
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