KININ Meaning and
Definition
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Kinin refers to a bioactive peptide that is part of the kinin-kallikrein system—an intricate system of proteins and enzymes found in the human body. Kinins are primarily involved in various physiological processes, including inflammation, blood pressure regulation, vasodilation, and pain transmission. They are derived from precursor molecules called kininogens, which are activated by specific enzymes known as kallikreins.
Kinin peptides have two main forms: bradykinin and kallidin. Bradykinin is the most well-known and extensively studied kinin, while kallidin is less abundant but shares similar actions. When kinins are released, typically in response to tissue injury or inflammation, they bind to specific cell surface receptors called B1 and B2 receptors. Activation of these receptors triggers a cascade of events resulting in inflammation, widening of blood vessels (vasodilation), increased vascular permeability, and stimulation of sensory nerve endings, leading to the perception of pain.
Due to their potent role in mediating pain and inflammation, kinins and their receptors have been targeted by pharmaceutical research. Antagonists of kinin receptors, or inhibitors of kinin production or degradation, have been investigated as potential therapeutic agents for various conditions such as hypertension, edema, and chronic pain.
Overall, kinins are crucial components of the human body's natural defense mechanisms, playing essential roles in the regulation of vascular tone, inflammation, and pain responses.
Common Misspellings for KININ
- kinen
- kinine
- iinin
- kunin
- kjnin
- kknin
- k9nin
- k8nin
- kibin
- kimin
- kijin
- kihin
- kinjn
- kinkn
- kin9n
- kin8n
- kinij
- kinih
- jkinin
- kjinin
Etymology of KININ
The word "kinin" is derived from the word "kine", an Old English term meaning "cattle" or "cows". In Middle English, the term "kine" was used specifically to refer to cows. The suffix "-in" is a common ending used in the naming of substances or compounds, indicating that "kinin" is a type of compound related to or derived from cows. The term "kinin" was first introduced in 1908 by the Polish physiologist Szymon Strzeminski to describe a group of vasoactive compounds found in the venoms of snakes, specifically regarding their impact on blood vessels.
Similar spelling words for KININ
- kimono,
- gin,
- Gaining,
- inning,
- joining,
- kinman,
- Kinnon,
- kink,
- king,
- canine,
- dining,
- lining,
- non-,
- known,
- Skinning,
- kin,
- kinyon,
- Coining,
- Fining,
- kan.,
- benin,
- linen,
- kiln,
- nun,
- nine,
- signing,
- kind,
- mining,
- kinnan,
- Kinking.
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