Kikuchi Fujimoto Disease, also known as Kikuchi disease or histiocytic necrotizing lymphadenitis, is a rare, benign, and self-limiting lymph node disorder that predominantly affects young adults. It was first described independently by two Japanese pathologists, Kikuchi and Fujimoto, in 1972.
This disease is characterized by enlarged, tender lymph nodes, usually affecting the cervical (neck) region, although it may also involve other sites including the axilla (armpit), groin, and mediastinum (chest). Individuals with Kikuchi Fujimoto Disease often present with symptoms such as fever, night sweats, fatigue, and weight loss.
Microscopically, Kikuchi Fujimoto Disease is characterized by the presence of necrotic (dead) areas within the lymph nodes, surrounded by clusters of histiocytes (immune cells) and peculiar crescent-shaped cells called plasmacytoid monocytes. These findings are typically seen in the absence of malignancy, and the disease is generally considered to be self-limiting, meaning it resolves on its own within a few weeks to months.
The exact cause of Kikuchi Fujimoto Disease remains unknown, although various theories have been proposed, including viral infections, altered immune responses, and genetic factors. Diagnosis of this condition typically involves a biopsy of an affected lymph node, which can confirm the presence of characteristic histopathological findings.
Although Kikuchi Fujimoto Disease can cause discomfort and distress, it is generally considered benign and does not require specific treatment. Symptomatic relief can be provided with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, if necessary. Close monitoring, however, is important to rule out other diseases and ensure
