Kartagener Triad, also known as Kartagener Syndrome, is a rare genetic disorder characterized by a combination of three primary symptoms, namely situs inversus, chronic sinusitis, and bronchiectasis.
Situs inversus refers to a condition where the internal organs are abnormally positioned in a mirror image reversal to their usual placement. In individuals with Kartagener Triad, the heart, liver, and other organs are positioned on the opposite side of where they are normally found. This abnormality can be present from birth and causes no major health concerns on its own.
Chronic sinusitis, a common symptom of the Kartagener Triad, refers to long-term inflammation of the sinus cavities. Sinuses are air-filled spaces within the skull that produce mucus, which helps to filter the air we breathe. In individuals with Kartagener Triad, chronic inflammation of the sinuses leads to recurring infections, nasal congestion, facial pain, and other sinus-related symptoms.
Bronchiectasis, another key component of the Kartagener Triad, is a condition characterized by the permanent enlargement and damage of the airways in the lungs. This leads to a chronic cough, excessive mucus production, recurrent respiratory infections, and breathing difficulties.
Kartagener Triad is a result of a genetic mutation that affects the functioning of specialized hair-like structures called cilia. Cilia are responsible for moving mucus and other substances through various organs, including the lungs and sinuses. In individuals with Kartagener Triad, the cilia are structurally abnormal or nonfunctional, leading to the characteristic symptoms. This condition is inherited in an autosomal recessive pattern, meaning both parents must carry the mutated gene for their child to be affected.
Treatment for Kart
