ISOASPARTIC ACID Meaning and
Definition
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Isoaspartic acid is a naturally occurring amino acid derivative that is formed by the non-enzymatic degradation of aspartic acid residues in proteins. It is characterized by the conversion of the α-carboxyl group of aspartic acid to a β-carboxyl group, resulting in a cyclic succinimide intermediate. This succinimide undergoes further hydrolysis to form isoaspartic acid.
Isoaspartic acid, also known as isoaspartyl residue or ISO residue, is commonly found in a variety of proteins over time due to the spontaneous rearrangement of peptide bonds. This modification can occur as a result of aging, stress, or exposure to certain conditions such as heat, UV radiation, or oxidative stress.
The presence of isoaspartic acid in proteins can have significant consequences on their function and structural integrity. It can disrupt the normal folding and stability of proteins, leading to alterations in their biological activity. Isoaspartic acid residues can also lead to protein aggregation, impair enzymatic activity, or interfere with protein-protein interactions.
Isoaspartic acid is often considered an undesirable modification in proteins, as it can contribute to protein misfolding and aggregation associated with various neurodegenerative diseases, such as Alzheimer's and Parkinson's. Therefore, the study of isoaspartic acid and its effects on protein structure and function is of great importance in understanding protein aging and disease progression.
In summary, isoaspartic acid is a modified amino acid formed by the non-enzymatic degradation of aspartic acid residues in proteins, and its presence can have detrimental effects on protein structure and function.
Common Misspellings for ISOASPARTIC ACID
- usoaspartic acid
- jsoaspartic acid
- ksoaspartic acid
- osoaspartic acid
- 9soaspartic acid
- 8soaspartic acid
- iaoaspartic acid
- izoaspartic acid
- ixoaspartic acid
- idoaspartic acid
- ieoaspartic acid
- iwoaspartic acid
- isiaspartic acid
- iskaspartic acid
- islaspartic acid
- ispaspartic acid
- is0aspartic acid
- is9aspartic acid
- isozspartic acid
- isosspartic acid
Etymology of ISOASPARTIC ACID
The word "Isoaspartic Acid" is derived from its molecular structure and composition.
The term "iso-" in chemistry refers to the presence of an extra carbon atom in the molecule, resulting in isomerism. In the case of isoaspartic acid, this refers to the arrangement of atoms around the carbon atom in the side chain of the amino acid.
"Aspartic" comes from the amino acid "aspartate", which is one of the 20 amino acids commonly found in proteins. Aspartate is derived from aspartic acid.
Lastly, "acid" refers to the carboxylic acid functional group present in isoaspartic acid, as in many other organic acids.
