How Do You Spell ISOASPARTATE?

Pronunciation: [ˈa͡ɪsə͡ʊspˌɑːte͡ɪt] (IPA)

Isoaspartate is a word used to describe a type of amino acid residue that occurs in proteins. The correct spelling of this word is /aɪsoʊəsˈpɑrtət/ and it is pronounced as eye-soh-uh-spahr-tuh. The IPA phonetic transcription shows that there are four syllables in the word and each syllable has its own distinct sound. The spelling of Isoaspartate may seem complicated, but it is important for scientists and researchers to accurately describe and analyze the structure of proteins.

ISOASPARTATE Meaning and Definition

1. Isoaspartate is a chemical compound that refers to an organic amino acid residue formed by the non-enzymatic isomerization of aspartate. It is structurally similar to aspartate but is characterized by the isomerization of the alpha-carboxyl group to a beta-carboxyl group, resulting in the formation of a cyclic structure. This process is known as the spontaneous deamidation or isomerization of aspartate residues. Isoaspartate is commonly found in proteins and peptides, where it can occur as a result of aging, oxidative stress, or other post-translational modifications.

   The formation of isoaspartate can have significant biological implications. It can affect protein structure, stability, and function due to the alteration of the peptide backbone and side chain interactions. Isoaspartate formation has been associated with protein misfolding and aggregation, leading to the development of various diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's disease.

   Detection and quantification of isoaspartate residues are essential in understanding its role in biological processes and disease states. Various analytical techniques such as mass spectrometry and nuclear magnetic resonance spectroscopy are used to identify and measure isoaspartate in proteins.

   Overall, isoaspartate is an isomer of aspartate that forms spontaneously in proteins through a non-enzymatic process. Its presence can have significant implications for protein structure and function, and its study is vital for understanding the role of protein modifications in various biological processes and disease development.

Common Misspellings for ISOASPARTATE

• usoaspartate
• jsoaspartate
• ksoaspartate
• osoaspartate
• 9soaspartate
• 8soaspartate
• iaoaspartate
• izoaspartate
• ixoaspartate
• idoaspartate
• ieoaspartate
• iwoaspartate
• isiaspartate
• iskaspartate
• islaspartate
• ispaspartate
• is0aspartate
• is9aspartate
• isozspartate
• isosspartate

Etymology of ISOASPARTATE

The word "isoaspartate" is a combination of two components: "iso-" and "aspartate".

- "Iso-" is a prefix commonly used in scientific and technical terms, derived from the Greek word "īsos", meaning "equal" or "same". It often indicates something similar or a modified version of the root word that follows.

- "Aspartate" refers to an amino acid, one of the building blocks of proteins. It is derived from "asparagus", as it was first isolated from asparagus juice.

Thus, "isoaspartate" refers to a modified or isomerized form of the amino acid aspartate. In proteins, isoaspartate can result from the spontaneous rearrangement or chemical modification of aspartate residues, potentially leading to protein dysfunction or degradation.