INDOXYL SULPHATE Meaning and
Definition
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Indoxyl sulfate is a chemical compound that consists of an indole ring connected to a sulfate group. It is derived from indole metabolism in the human body and is primarily produced in the intestine by the bacterial breakdown of dietary tryptophan. Indoxyl sulfate is then absorbed into the bloodstream and circulates throughout the body.
Indoxyl sulfate is primarily known for its role as a uremic toxin, meaning it is a toxic substance that accumulates in individuals with kidney dysfunction. In healthy individuals, the kidneys efficiently clear indoxyl sulfate from the body. However, in patients with impaired kidney function, indoxyl sulfate levels can rise significantly, leading to various detrimental effects.
Research suggests that indoxyl sulfate can act as a pro-inflammatory molecule, promoting oxidative stress and vascular damage. Moreover, it has been associated with the progression of chronic kidney disease, cardiovascular disease, and other complications. Studies have also indicated potential neurotoxic effects, showing a correlation between elevated levels of indoxyl sulfate and cognitive impairment or neurodegenerative diseases.
Due to its implications in disease progression and adverse health outcomes, indoxyl sulfate has become a target of interest in both clinical and therapeutic investigations. Researchers aim to develop strategies that effectively lower its levels or inhibit its production to mitigate the toxic effects associated with kidney dysfunction and related diseases.
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A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for INDOXYL SULPHATE
- undoxyl sulphate
- jndoxyl sulphate
- kndoxyl sulphate
- ondoxyl sulphate
- 9ndoxyl sulphate
- 8ndoxyl sulphate
- ibdoxyl sulphate
- imdoxyl sulphate
- ijdoxyl sulphate
- ihdoxyl sulphate
- insoxyl sulphate
- inxoxyl sulphate
- incoxyl sulphate
- infoxyl sulphate
- inroxyl sulphate
- ineoxyl sulphate
- indixyl sulphate
- indkxyl sulphate
- indlxyl sulphate
- indpxyl sulphate
Etymology of INDOXYL SULPHATE
The word "indoxyl" is derived from the combination of two elements: "indo-" and "-xyl".
The prefix "indo-" originates from the Indigofera plant, which has been historically used to produce indigo dye, hence "indigo". "Indigo" itself comes from the Latin word "indicum", meaning "of India" or "Indian". This is because the Indigofera plant was commonly cultivated in India.
The suffix "-xyl" is derived from "-xylol" or "xylene", which refers to a group of isomeric hydrocarbon compounds. The term is originally derived from the Greek word "xylon", meaning "wood", as xylene was initially obtained from wood tar.
The word "sulphate" refers to a salt or ester of sulfuric acid.
Similar spelling word for INDOXYL SULPHATE
